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Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.
- Zhibo Yang, S. Rayala, D. Nguyen, R. Vadlamudi, Shiuan Chen, Rakesh Kumar
- BiologyCancer research
- 15 April 2005
It is found for the first time that Pak1 promotes transcription repression activity of Snail from E-cadherin, occludin, and aromatase promoters and represents a novel mechanism by which a signaling kinase might contribute to the process of epithelial-mesenchymal transition.
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors.
- M. Suetsugi, L. Su, K. Karlsberg, Yate-Ching Yuan, Shiuan Chen
- BiologyMolecular cancer research : MCR
- 1 November 2003
Recent ERR research has determined for the first time that flavone and isoflavone phytoestrogens are agonists of ERRs, and an approach that combines structure-based virtual screening and receptor functional assays can identify novel ligands of orphan nuclear receptors.
Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro
- Lynn S. Adams, Yanjun Zhang, N. Seeram, D. Heber, Shiuan Chen
- Biology, ChemistryCancer Prevention Research
- 1 January 2010
Pomegranate ET–derived compounds have potential for the prevention of estrogen-responsive breast cancers, and urolithin B (UB) was shown to most effectively inhibit aromatase activity in a live cell assay.
Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway.
- Lynn S. Adams, S. Phung, Natalie Yee, N. Seeram, Liya Li, Shiuan Chen
- Biology, ChemistryCancer research
- 1 May 2010
The inhibitory effect of blueberry phytochemicals on the growth and metastatic potential of MDA-MB-231 cells through modulation of the PI3K/AKT/NFkappaB pathway is illustrated.
Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction
Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.
This study shows that ERRs, which are coexpressed with ERs in prostatic cells, could regulate cell growth and modulate ER-mediated pathways via interference on ERalpha transcription in prostatics cells.
Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells.
- Liya Li, Lynn S. Adams, Shiuan Chen, C. Killian, Aftab Ahmed, N. Seeram
- Biology, ChemistryJournal of agricultural and food chemistry
- 11 February 2009
It is suggested that Jamun fruit extract (JFE) may have potential beneficial effects against breast cancer.
ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer.
It is shown that ERRgamma was expressed in epithelial cell nuclei in fetal and pubertal human prostates, whereas its nuclear expression became reduced in advanced prostate cancer lesions, and that it could be a novel therapeutic target for prostate cancer treatment.
Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha.
It was found that E(2) up-regulates aromatase expression by a nongenomic action of ER alpha via cross-talk with growth factor-mediated pathways and could be suppressed by the mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor, PD98059, and the epidermal growth factor receptor tyrosine kinase inhibitors, PD153035 hydrochloride.
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor.
Characterization of resistant lines showed that LTEDaro, T+LET R, and T+ANA R cells contained a constitutively active estrogen receptor (ER)alpha that does not require estrogen for activation, which is critical in overcoming resistance when treating hormone-responsive breast cancers.