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Morphological development of the gonads in zebrafish
Gonadogenesis of zebrafish Danio rerio was investigated by means of light microscopy to test the suitability of gonad histology as an endpoint in hazard assessment of endocrine-active compounds. AtExpand
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Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project.
The EU-funded project IDEA aimed to evaluate (a) what parameters and endpoints allow the detection of endocrine-mediated developmental and reproductive effects of (xeno)estrogens in life cycle- andExpand
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Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption.
  • H. Segner
  • Biology, Medicine
  • Comparative biochemistry and physiology…
  • 1 March 2009
Endocrine-disrupting compounds (EDCs) are widespread in the aquatic environment and can cause alterations in development, physiological homeostasis and health of vertebrates. Zebrafish, Danio rerio,Expand
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Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio).
This study investigated whether gonadal sex differentiation of zebrafish (Danio rerio) is susceptible to compounds that interfere with cytochrome P450 aromatase (P450arom). Treatment of zebrafishExpand
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Concentration- and Time-dependent Effects of the Synthetic Estrogen, 17α-ethinylestradiol, on Reproductive Capabilities of the Zebrafish, Danio rerio
Partial or full life-cycle tests are needed to assess the potential of endocrine-disrupting compounds (EDCs) to adversely affect development and reproduction of fish. Small fish species such asExpand
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An environmentally relevant concentration of estrogen induces arrest of male gonad development in zebrafish, Danio rerio.
The aim of the present study was to elucidate how full life-cycle exposure to estrogens impacts zebrafish development and reproduction, compared to partial life-cycle exposure only, and whether theExpand
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The use of Fish Cells in Ecotoxicology: The Report and Recommendations of ECVAM Workshop 471, 2
This is the report of the forty-seventh of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by itsExpand
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Isolation and primary culture of teleost hepatocytes
Abstract The review discusses procedures for isolation and primary culture of teleostean hepatocytes and the influence of different culture conditions on the physiology of the cells in vitro. As aExpand
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Screening and Testing for Endocrine Disruption in Fish—Biomarkers As “Signposts,” Not “Traffic Lights,” in Risk Assessment
Biomarkers are currently best used as mechanistic “signposts” rather than as “traffic lights” in the environmental risk assessment of endocrine-disrupting chemicals (EDCs). In field studies,Expand
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Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish.
Many natural and synthetic compounds present in the environment exert a number of adverse effects on the exposed organisms, leading to endocrine disruption, for which they were termed endocrineExpand
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