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Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment.
Ecological risk assessors face increasing demands to assess more chemicals, with greater speed and accuracy, and to do so using fewer resources and experimental animals. New approaches in biologicalExpand
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Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas).
Due to the time and expense associated with full life-cycle testing, most current toxicity tests with fish do not explicitly consider reproductive output as an endpoint but, rather, focus on earlyExpand
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Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow.
Trenbolone acetate is a synthetic steroid that is extensively used in the United States as a growth promoter in beef cattle. The acetate is administered to livestock via slow-release implants; someExpand
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Technical basis and proposal for deriving sediment quality criteria for metals : Metal bioavailability in sediments
In developing sediment quality criteria (SQC) for metals, it is essential that bioavailability be a prime consideration. Different studies have shown that while dry weight metal concentrations inExpand
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Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas).
Cytochrome P450 aromatase (CYP19) is a key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to C18 estrogens such as beta-estradiol (E2). The objective of this studyExpand
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Acid volatile sulfide predicts the acute toxicity of cadmium and nickel in sediments
Laboratory toxicity tests using amphipods, oligochaetes, and snails with spiked freshwater and marine sediments and with contaminated sediments collected from an EPA Superfund site demonstrate thatExpand
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Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas).
The fathead minnow (Pimephales promelas) has been proposed as a model species for assessing the adverse effects of endocrine-disrupting chemicals (EDCs) on reproduction and development. The purposeExpand
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Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas).
Perfluorooctanesulfonate (PFOS) is a widespread environmental contaminant emanating from the production and/or metabolism of fluorinated chemicals with a variety of applications. The goal of thisExpand
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INTERACTIONS BETWEEN CHEMICAL AND CLIMATE STRESSORS: A ROLE FOR MECHANISTIC TOXICOLOGY IN ASSESSING CLIMATE CHANGE RISKS
Incorporation of global climate change (GCC) effects into assessments of chemical risk and injury requires integrated examinations of chemical and nonchemical stressors. Environmental variablesExpand
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The fathead minnow in aquatic toxicology: past, present and future.
This paper reviews the roles of the fathead minnow (Pimephales promelas) as a small fish model in the field of aquatic toxicology. The species has been (and is) extensively used both for regulatoryExpand
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