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Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment.
TLDR
A framework designed for this purpose, the adverse outcome pathway (AOP), is discussed, a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. Expand
Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas).
TLDR
The utility of this short-term reproduction test with the fathead minnow is demonstrated for identifying chemicals that exert reproductive toxicity through alterations in endocrine systems controlled by estrogens and androgens. Expand
Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow.
TLDR
The studies indicate that 17-beta-trenbolone is a potent androgen and reproductive toxicant in fish and further studies are warranted to assess potential ecological risk. Expand
Technical basis and proposal for deriving sediment quality criteria for metals : Metal bioavailability in sediments
In developing sediment quality criteria (SQC) for metals, it is essential that bioavailability be a prime consideration. Different studies have shown that while dry weight metal concentrations inExpand
Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas).
TLDR
Results of this study indicate that the proposed fathead minnow assay should effectively identify test chemicals as potential aromatase inhibitors, both in the context of their reproductive toxicity and the specific mechanism of action. Expand
Acid volatile sulfide predicts the acute toxicity of cadmium and nickel in sediments
Laboratory toxicity tests using amphipods, oligochaetes, and snails with spiked freshwater and marine sediments and with contaminated sediments collected from an EPA Superfund site demonstrate thatExpand
INTERACTIONS BETWEEN CHEMICAL AND CLIMATE STRESSORS: A ROLE FOR MECHANISTIC TOXICOLOGY IN ASSESSING CLIMATE CHANGE RISKS
TLDR
This work employed adverse outcome pathways, constructs depicting linkages between mechanism-based molecular initiating events and impacts on individuals or populations, to assess how chemical- and climate-specific variables interact to lead to adverse outcomes. Expand
Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas).
TLDR
Water and tissue concentrations of PFOS associated with effects in this study exceeded those reported for samples collected from the field by two to three orders of magnitude, suggesting that the current risk ofPFOS on aspects of fish reproduction and development assessed would be small. Expand
The fathead minnow in aquatic toxicology: past, present and future.
TLDR
Attributes of the fathead minnow make it an excellent model for addressing new challenges in aquatic toxicology, including identification of sensitive life-stages/endpoints for chemicals with differing modes/mechanisms of action, predicting population-level effects based on data collected from lower levels of biological organization, and exploring the emerging role of genomics in research and regulation. Expand
Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas).
The fathead minnow (Pimephales promelas) has been proposed as a model species for assessing the adverse effects of endocrine-disrupting chemicals (EDCs) on reproduction and development. The purposeExpand
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