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Counterregulatory actions of angiotensin-(1-7).
The accumulating evidence suggests that Ang-(1-7) may oppose the actions of Ang II either directly or by stimulation of prostaglandins and nitric oxide, which may explain the effective antihypertensive action of converting enzyme inhibitors in a variety of non-renin-dependent models of experimental and genetic hypertension as well as most forms of human hypertension. Expand
Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide.
The results suggest that increases in circulating levels of Ang-(1-7) accompanying long-term administration of converting enzyme inhibitors or Ang II receptor blockers may contribute to the cardioprotective actions of these drugs. Expand
Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease.
- D. Herrington, T. Howard, +6 authors E. Bleecker
- The New England journal of medicine
- 28 March 2002
Postmenopausal women with coronary disease who have the ER-alpha IVS1-401 C/C genotype, or several other closely related genotypes, have an augmented response of HDL cholesterol to hormone-replacement therapy. Expand
Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors
- Y. Ishiyama, P. Gallagher, D. Averill, E. Tallant, K. Brosnihan, C. Ferrario
- 1 May 2004
Evidence is provided for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotENSin-(1–7). Expand
Common Estrogen Receptor Polymorphism Augments Effects of Hormone Replacement Therapy on E-Selectin but Not C-Reactive Protein
Women with the ER-&agr; IVS1-401 C/C genotype have greater reductions in E-selectin but no further increases in CRP with HRT, and possible mechanisms by which this polymorphism might influence estrogen action are explored. Expand
Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis
Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats.
- S. Lindsey, Jonathan A Cohen, K. Brosnihan, P. Gallagher, M. Chappell
- Biology, Medicine
- 1 August 2009
It is concluded that the novel estrogen receptor GPR30 may contribute to the beneficial cardiovascular actions of estrogen in female mRen2.Lewis rats through regulation of vascular components of the renin-angiotensin system. Expand
A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11.
This review summarizes the physical characteristics and distribution of angiotensin converting enzyme (E.C. 220.127.116.11), a known Ang I processing enzyme, and compares its features to what is known of prolyl endopeptidase and neutral endopePTidase 24.24.11. Expand
Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RAS.
- K. Brosnihan, P. Li, D. Ganten, C. Ferrario
- Biology, Medicine
- The American journal of physiology
- 1 December 1997
Findings provide the first evidence demonstrating that estrogen is protective against hypertension, possibly by amplifying the vasodilator contributions of ANG-(1-7), while reducing the formation and vasoconstrictor actions of ANG II. Expand
Angiotensin-(1–7) in normal and preeclamptic pregnancy
For the first time, increased plasma Ang-(1–7) in normal pregnant subjects compared with nonpregnant subjects and decreased Ang-1-7 in preeclamptic Subjects compared with normal pregnantSubjects had no previous history of hypertension or renal, connective-tissue, or metabolic disease, but at the time of delivery had significant hypertension and proteinuria. Expand