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Clostridium difficile is recognized as an important nosocomial pathogen. C. difficile infection (CDI) is thought to arise as a… Expand MICs of six oral cephalosporins (cefdinir, cefpodoxime, cefaclor, cefuroxime, cefixime and Ro 40-6890), four quinolones… Expand Cefotaxime and ceftriaxone have proven to be effective in pyogenic infections of the central nervous system. Since in some… Expand Since clinical trials comparing the efficacies of different antibiotic regimens for treatment of brain abscesses are difficult to… Expand Eighty-seven organisms were tested against ceftriaxone, cefotaxime, desacetylcefotaxime, and the combination of cefotaxime and… Expand The pharmacokinetics and cerebrospinal fluid (CSF) penetration of cefotaxime (Ctx) and desacetylcefotaxime (dCtx) were evaluated… Expand : Although the antibacterial activity of desacetylcefotaxime (des-CTX), the principal metabolite of cefotaxime (CTX), is… Expand Cefotaxime is metabolized to 3-desacetylcefotaxime. The antibacterial activity of desacetylcefotaxime is four- to eightfold less… Expand The level of antimicrobial activity of 3-desacetylcefotaxime was found to be approximately eightfold lower than that of… Expand