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Post-antibiotic suppressive effect of ciprofloxacin against gram-positive and gram-negative bacteria.
Results support less frequent dosing programs for ciprofloxacin in the treatment of tissue and urinary infections and show an excellent PAE for most gram-negative bacteria and for S. aureus and E. coli.
Cefotaxime and desacetylcefotaxime: an example of advantageous antimicrobial metabolism.
The antibacterial activity of the combination of CTX/des-CTX indicates that the drug can be administered every 8-12 hr and provides excellent, broad-spectrum antimicrobial activity.
A perspective on the present contribution of beta-lactamases to bacterial resistance with particular reference to induction of beta-lactamase and its clinical significance.
Inducible chromosomally mediated beta-lactamases in species such as Enterobacter, Pseudomonas, Citrobacter and some Serratia have become an increasing problem with more widespread use of beta- lactamase stable cephalosporins.
The activity and beta-lactamase stability of cefotetan compared to other beta-lactam antibiotics.
Cefotetan was as active as cefoxitin against anaerobic species such as Bacteroides fragilis and Clostridium and was not hydrolyzed by cephalosporinases of Richmond-Sykes type Ia or Id.
Synergy of fosfomycin with beta-lactam antibiotics against staphylococci and aerobic gram-negative bacilli.
The combination of fosfomycin with beta-lactams may be clinically useful in selected situations, particularly for methicillin-resistant staphylococci and beta- lactam-resistant P. aeruginosa.
Synergy of sulbactam and ampicillin against methicillin-resistant staphylococci.
Synergy of sulbactam and ampicillin could be demonstrated against MRSA by the agar fixed ratio method, checkerboard dilution and by killing curves, suggesting that in certain situations MRSA and MRSE may be effectively eliminated by this method.