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Cefotaxime
Known as:
Cefotaxim
, Céfotaxime
, (6R,7R)-3-(Acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and…
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National Institutes of Health
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Related topics
Related topics
41 relations
Acinetobacter Infections
Bacterial Infections
Bone Diseases, Infectious
Cefotaxime 1000 MG Injection
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Broader (1)
Anti-Bacterial Agents
Narrower (10)
Biosint
Cefotaxime Sodium
Claforan
HR-756
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
D. Yong
,
M. Toleman
,
+4 authors
T. Walsh
Antimicrobial Agents and Chemotherapy
2009
Corpus ID: 740000
ABSTRACT A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a…
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Review
2009
Review
2009
AmpC β-Lactamases
G. Jacoby
Clinical Microbiology Reviews
2009
Corpus ID: 25382533
SUMMARY AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae…
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Review
2004
Review
2004
Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes
R. Bonnet
Antimicrobial Agents and Chemotherapy
2004
Corpus ID: 11642384
The production of β-lactamases is the predominant cause of resistance to β-lactam antibiotics in gram-negative bacteria. These…
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Highly Cited
2003
Highly Cited
2003
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
E. Jonge
,
M. Schultz
,
+4 authors
J. Kesecioglu
The Lancet
2003
Corpus ID: 25862229
Highly Cited
1999
Highly Cited
1999
Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis.
P. Sort
,
M. Navasa
,
+9 authors
J. Rodés
New England Journal of Medicine
1999
Corpus ID: 33758412
BACKGROUND In patients with cirrhosis and spontaneous bacterial peritonitis, renal function frequently becomes impaired. This…
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Review
1995
Review
1995
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins.
W. Craig
Diagnostic microbiology and infectious disease
1995
Corpus ID: 37138879
Highly Cited
1994
Highly Cited
1994
Rapid evolution of a protein in vitro by DNA shuffling
W. Stemmer
Nature
1994
Corpus ID: 4363498
DNA SHUFFLING is a method for in vitro homologous recombination of pools of selected mutant genes by random fragmentation and…
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Highly Cited
1988
Highly Cited
1988
Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.
V. Jarlier
,
M. Nicolas
,
G. Fournier
,
A. Philippon
Reviews of Infectious Diseases
1988
Corpus ID: 21938834
Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of…
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Review
1988
Review
1988
Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
D. Campoli-Richards
,
J. Monk
,
A. H. Price
,
P. Benfield
,
P. A. Todd
,
A. Ward
Drugs
1988
Corpus ID: 195697528
Ciprofloxacin is one of a new generation of fluorinated quinolones structurally related to nalidixic acid. The primary mechanism…
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Highly Cited
1983
Highly Cited
1983
Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens
Prof. Dr. H. Knothe
,
P. D. P. Shah
,
Dr. V. Krcmery
,
Dr. M. Antal
,
Prof. Dr. S. Mitsuhashi
Infection
1983
Corpus ID: 36562012
SummaryIn conjugational crosses, threeKlebsiella pneumoniae strains and oneSerratia marcescens strain have been demonstrated to…
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