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cytotoxic T-lymphocyte antigen 4

Known as: mdx-ctla4, Cytotoxic T Lymphocyte Associated Antigen 4, Cytotoxic T-Lymphocyte-Associated Antigen 4 
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative… 
National Institutes of Health

Related topics

Related topics

12 relations
CD28 AntigensCTLA-4-IgCTLA4 geneCTLA4 wt Allele

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CTLA4 protein, human

Papers overview

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2019
2019
A Phase 1 study of AK104, a tetrameric bispecific antibody that targets PD-1 and CTLA-4 in patients with advanced solid tumors
2016
2016
Manipulation of Regulatory Cells’ Responses to Treatments for Chronic Hepatitis B Virus Infection
Background Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although… 
2015
2015
Hashimoto’s Thyroiditis in Adolescents
In the last decade, discoveries in molecular biology field have allowed new insight into the genes involved in the development of… 
Review
2012
Review
2012
Molecular genetic studies of multiple sclerosis in the portuguese population.
Multiple sclerosis (MS) is a chronic neuroinflammatory autoimmune disease believed to arise from complex interactions of both… 
2011
2011
Dual fronts poised to transform melanoma therapy
With recent successes of immunotherapies and targeted drugs, melanoma has become one of the most dynamic areas of anticancer drug… 
2007
2007
Antigenic Disparity Impacts Outcome of Agonism but Not Blockade of Costimulatory Pathways in Experimental Transplant Models
Treatment regimens consisting of CTLA‐4 Ig/anti‐CD154 or agonistic anti‐CD28/rapamycin have both been shown to prevent GVHD in… 
2002
2002
CTLA 4 Ig Inhibits Alloantibody Responses to Repeated Blood Transfusions By
Allosensitization is a fundamental problem that limits the effectiveness of blood transfusions. Patients who receive multiple… 
2001
2001
B 7-dependent T-cell costimulation in mice lacking CD 28 and CTLA 4
The B7/CD28/CTLA4 pathway plays a critical role in the regulation of T-cell activation and has great potential as a therapeutic… 
2000
2000
CTLA 4 Ig inhibits T cell – dependent B-cell maturation in murine systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is characterized by dysregulated activation of both T and B lymphocytes with the development… 
1998
1998
Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease.
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4, CD152) is a molecule expressed on in vitro activated T cells. CTLA-4 shares… 
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