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cytotoxic T-lymphocyte antigen 4

Known as: mdx-ctla4, Cytotoxic T Lymphocyte Associated Antigen 4, Cytotoxic T-Lymphocyte-Associated Antigen 4 
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4 (CTLA-4), anti-programmed cell death 1 (PD-1… Expand
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Review
2019
Review
2019
A better knowledge of the complex interactions between cancer cells and the immune system has led to novel immunotherapy… Expand
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Review
2019
Review
2019
Following initial successes in melanoma treatment, immunotherapy has rapidly become established as a major treatment modality for… Expand
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Review
2019
Review
2019
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1… Expand
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Highly Cited
2009
Highly Cited
2009
Tumor antigen-specific T cells are found within melanomas, yet tumors continue to grow. Although the tumor microenvironment is… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice… Expand
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Highly Cited
2001
Highly Cited
2001
Therapeutic efficacy of a tumor cell–based vaccine against experimental B16 melanoma requires the disruption of either of two… Expand
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Highly Cited
1995
Highly Cited
1995
The importance of the B7/CD28/CTLA-4 molecules has been established in studies of antigen-presenting cell-derived B7 and its… Expand
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Highly Cited
1994
Highly Cited
1994
CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following antigen receptor engagement provides a… Expand
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Highly Cited
1991
Highly Cited
1991
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T… Expand
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