Skip to search formSkip to main contentSkip to account menu

cytotoxic T-lymphocyte antigen 4

Known as: mdx-ctla4, Cytotoxic T Lymphocyte Associated Antigen 4, Cytotoxic T-Lymphocyte-Associated Antigen 4 
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative… 
National Institutes of Health

Related topics

Related topics

12 relations
CD28 AntigensCTLA-4-IgCTLA4 geneCTLA4 wt Allele

Narrower (1)

CTLA4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells
Immunotherapy using checkpoint-blocking antibodies against targets such as CTLA-4 and PD-1 can cure melanoma and non–small cell… 
Review
2014
Review
2014
Checkpoint blocking antibodies in cancer immunotherapy
Highly Cited
2006
Highly Cited
2006
TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells1
Although positive CD28 costimulation is needed for the generation of natural CD4+CD25+ regulatory T cells, we report that… 
Highly Cited
2005
Highly Cited
2005
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
CD4+ CD25+ regulatory T (Treg) cells play a critical role in the maintenance of peripheral tolerance and the prevention of… 
Highly Cited
2004
Highly Cited
2004
Cytotoxic T-Lymphocyte Antigen 4 Gene and Recovery from Hepatitis B Virus Infection
ABSTRACT Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an inhibitory T-cell receptor expressed by activated and regulatory T cells… 
Highly Cited
2004
Highly Cited
2004
New drugs for rheumatoid arthritis [6] (multiple letters)
Highly Cited
2001
Highly Cited
2001
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell… 
Highly Cited
1998
Highly Cited
1998
Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might… 
Review
1997
Review
1997
The emerging role of CTLA-4 as an immune attenuator.
Highly Cited
1996
Highly Cited
1996
CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.
The B7 family of cell surface molecules expressed on APC provides accessory signals to T cells via either CD28 or CTLA-4. However… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)