cytotoxic T-lymphocyte antigen 4

Known as: mdx-ctla4, Cytotoxic T Lymphocyte Associated Antigen 4, Cytotoxic T-Lymphocyte-Associated Antigen 4 
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
010020019702018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Several cancers are highly refractory to conventional chemotherapy. The survival of tumors in several cases is assisted by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Review
2017
Review
2017
Anti-tumor immunity is a new line of research for the treatment of patients with solid tumors. In this field, negative regulators… (More)
  • figure 1
  • table 1
Is this relevant?
Highly Cited
2006
Highly Cited
2006
PURPOSE Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice… (More)
  • table 2
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an inhibitory T-cell receptor expressed by activated and regulatory T cells. We… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
CD28 and CTLA-4 engagement with B7 expressed by APCs generates critical regulatory signals for T cell activation. CD28 is… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The cytotoxic T-lymphocyte antigen 4 (CTLA4) is an important modifier of T-cell activation with down-regulatory properties upon… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2002
Highly Cited
2002
A common T17A polymorphism in the signal peptide of the cytotoxic T-lymphocyte antigen 4 (CTLA-4), a T-cell receptor that… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Therapeutic efficacy of a tumor cell-based vaccine against experimental B16 melanoma requires the disruption of either of two… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Endocrine autoimmune disorders share susceptibility and resistance factors of the human leukocyte antigen system on the short arm… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?