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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
While the catalog of mammalian transcripts and their expression levels in different cell types and disease states is rapidly expanding, our understanding of transcript function lags behind. We… Expand
CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the… Expand
A membrane protein required for dislocation of misfolded proteins from the ER
After insertion into the endoplasmic reticulum (ER), proteins that fail to fold there are destroyed. Through a process termed dislocation such misfolded proteins arrive in the cytosol, where… Expand
Predominant Autoantibody Production by Early Human B Cell Precursors
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies… Expand
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA end-joining protein has recently been shown to suppress apoptosis by… Expand
Multiple associated proteins regulate proteasome structure and function.
We have identified proteins that are abundant in affinity-purified proteasomes, but absent from proteasomes as previously defined because elevated salt concentrations dissociate them during… Expand
Regulation of monoubiquitinated PCNA by DUB autocleavage
Monoubiquitination is a reversible post-translational protein modification that has an important regulatory function in many biological processes, including DNA repair. Deubiquitinating enzymes… Expand
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- T. Maruyama, S. Dougan, Matthias C Truttmann, Angelina M. Bilate, Jessica R Ingram, H. Ploegh
- Biology, Medicine
- Nature Biotechnology
- 1 March 2015
Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome… Expand
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
Signalling by means of toll-like receptors (TLRs) is essential for the development of innate and adaptive immune responses. UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and… Expand