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CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
TLDR
A myeloid-derived mucosal DC in mice is identified, which populates the entire lamina propria of the small intestine, and CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
A membrane protein required for dislocation of misfolded proteins from the ER
TLDR
It is shown that US11 uses its transmembrane domain to recruit class I MHC products to a human homologue of yeast Der1p, a protein essential for the degradation of a subset of misfolded ER proteins.
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
TLDR
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules, which involves the Sec6l complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
TLDR
This work targeted DNA ligase IV, a key enzyme in the NHEJ pathway, using the inhibitor Scr7, and increased the efficiency of HDR-mediated genome editing, using Cas9 in mammalian cell lines and in mice for all four genes examined.
Regulation of monoubiquitinated PCNA by DUB autocleavage
TLDR
This work shows that the DUB ubiquitin specific protease 1 (USP1) deubiquitinates the DNA replication processivity factor, PCNA, as a safeguard against error-prone translesion synthesis (TLS) of DNA.
Herpes simplex virus turns off the TAP to evade host immunity
TLDR
It is shown here that ICP47 binds to TAP and prevents peptide translocation into the endoplasmic reticulum.
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