Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells

@article{Doyle2001InductionOC,
  title={Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells},
  author={Alden M Doyle and Alan C. Mullen and Alejandro V Villarino and Anne S. Hutchins and Frances A. High and Hubert W. Lee and Craig B Thompson and Steven L Reiner},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={893 - 902}
}
Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansion of proliferating CD4(+) T cells. The regulation of CTLA-4 expression and function ensures that, after approximately 3 cell divisions of expansion, most progeny will succumb to either proliferative… CONTINUE READING

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