Skip to search formSkip to main contentSkip to account menu

CTLA4 wt Allele

Known as: CD, IDDM12, ALPS5 
Human CTLA4 wild-type allele is located within 2q33 and is approximately 6 kb in length. This allele, which encodes cytotoxic T-lymphocyte protein 4… 
National Institutes of Health

Related topics

Related topics

13 relations
2q33CTLA4 protein, humanCeliac DiseaseDiabetes Mellitus, Insulin-Dependent

Broader (1)

CTLA4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Down-Regulation of ICOS Ligand by Interaction with ICOS Functions as a Regulatory Mechanism for Immune Responses1
Although it is well-known that the ICOS-ICOS ligand (ICOSL) costimulatory pathway is important for many immune responses, recent… 
2008
2008
Disease control and long-term survival in chemotherapy-naive patients with advanced melanoma treated with ipilimumab (MDX- 010) with or without dacarbazine
9022 Background: Ipilimumab is a fully human monoclonal antibody targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) that gave… 
Review
2007
Review
2007
A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance?
Occupancy of the antigen receptor is not sufficient for activation of naïve T cells--additional co-stimulatory signals are… 
Highly Cited
2005
Highly Cited
2005
Short-term accumulation of Cd and Cu from water, sediment and algae by the amphipod Melita plumulosa and the bivalve Tellina deltoidalis
The benthic organisms Melita plumulosa (amphipod) and Tellina deltoidalis (bivalve) are currently being used as test species for… 
2005
2005
CTLA‐4 gene 49A/G polymorphism in Turkish patients with Behçet's disease
Genetic factors predisposing individuals to Behçet's disease (BD) are considered to play important roles in the development of… 
Highly Cited
2001
Highly Cited
2001
ICOS ligand costimulation is required for T-cell encephalitogenicity.
The interaction of ICOS with its ligand on APC provides a costimulatory signal to previously activated T-cells. In these studies… 
Highly Cited
2001
Highly Cited
2001
CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
Graves' disease (GD) is an organ-specific autoimmune disorder of multifactorial etiology with a polygenic mode of inheritance. A… 
Highly Cited
1998
Highly Cited
1998
CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.
We have assessed the functional effects of a panel of CTLA-4 mAbs on resting human CD4+ T cells. Our results demonstrate that… 
Highly Cited
1998
Highly Cited
1998
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
In the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5 , has been mapped… 
Review
1996
Review
1996
CTLA‐4, a Negative Regulator of T‐Lymphocyte Activation
The activation of T cells is controlled by a delicate co-ordination of stimulatory and negative regulatory signals. The… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)