CTLA4 wt Allele

Known as: CD, IDDM12, ALPS5 
Human CTLA4 wild-type allele is located within 2q33 and is approximately 6 kb in length. This allele, which encodes cytotoxic T-lymphocyte protein 4… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes… (More)
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Highly Cited
2014
Highly Cited
2014
Cytotoxic T lymphocyte antigen–4 (CTLA-4) is an inhibitory receptor found on immune cells. The consequences of mutations in CTLA4… (More)
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Highly Cited
2013
Highly Cited
2013
Seasonal influenza vaccine protects 60 to 90% of healthy young adults from influenza infection. The immunological events that… (More)
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Highly Cited
2008
Highly Cited
2008
ICOS is an important regulator of T cell effector function. ICOS-deficient patients as well as knockout mice show severe defects… (More)
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Highly Cited
2006
Highly Cited
2006
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying… (More)
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Highly Cited
2004
Highly Cited
2004
Both CTLA-4 and TGF-beta have been implicated in suppression by CD4+CD25+ regulatory T cells (Treg). In this study, the… (More)
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Highly Cited
2001
Highly Cited
2001
The outcome of T-cell responses after T-cell encounter with specific antigens is modulated by co-stimulatory signals, which are… (More)
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Highly Cited
2001
Highly Cited
2001
Type 1 diabetes (T1D) is a genetically complex disorder of glucose homeostasis that results from the autoimmune destruction of… (More)
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Highly Cited
1996
Highly Cited
1996
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and… (More)
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Highly Cited
1996
Highly Cited
1996
Experimental data suggest that negative selection of thymocytes can occur as a result of supraoptimal antigenic stimulation. It… (More)
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