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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
TLDR
In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
TLDR
It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
TLDR
RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection provides new insights into the genetic regulation of HCV clearance and its clinical management.
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
TLDR
The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
An Update on Treatment of Genotype 1 Chronic Hepatitis C Virus Infection: 2011 Practice Guideline by the American Association for the Study of Liver Diseases
TLDR
These guidelines review what treatment for genotype 1 chronic HCV infection is now regarded as optimal, but they do not address the issue of prioritization of patient selection for treatment or of treatment of special patient populations.
Occult hepatitis B.
Diagnosis, management, and treatment of hepatitis C
TLDR
Intended for use by physicians, these recommendations suggest preferred approaches to the diagnostic, therapeutic and preventive aspects of care to be flexible, in contrast to standards of care, which are inflexible policies to be followed in every case.
Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel.
TLDR
New recommendations for HIV patient care include offering ART to all patients regardless of CD4 cell count, changes in therapeutic options, and modifications in the timing and choice of ART in the setting of opportunistic illnesses such as cryptococcal disease and tuberculosis.
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
TLDR
Production of infectious genotype 1a HCV in cells transfected with synthetic RNA derived from a prototype virus (H77-S) is described, which will substantially benefit antiviral and vaccine discovery programs.
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