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bruceantin

Known as: 2H-3, 11c-(Epoxymethano)phenanthro[10,1-bc]pyran, Picras-3-en-21-oic Acid Derivative, Picras-3-en-21-oic acid, 15-[(3, 4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2, 16-dioxo-, methyl ester, [11.beta.,12.alpha.,15.beta.(E)]-, [11Beta,12alpha,15beta(E)]-15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxopicras-3-en-21-oic Acid Methyl Ester 
A triterpene quassinoid antineoplastic antibiotic isolated from the plant Brucea antidysenterica. Bruceantin inhibits the peptidyl transferase… 
National Institutes of Health

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Quassins

Papers overview

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Highly Cited
2004
Highly Cited
2004
Multiple Myeloma Regression Mediated by Bruceantin
Purpose: Bruceantin has been shown to induce cell differentiation in a number of leukemia and lymphoma cell lines. It also down… 
2004
2004
A Phase II study of Bruceantin (NSC-165, 563) in advanced malignant melanoma
SummaryThe Eastern Cooperative Oncology Group (ECOG) conducted a Phase II trial of Bruceantin in malignant melanoma. Twenty-two… 
Highly Cited
1987
Highly Cited
1987
23S ribosomal RNA mutations in halobacteria conferring resistance to the anti-80S ribosome targeted antibiotic anisomycin.
Halobacterium (H.) halobium and H. cutirubrum mutants resistant to the anti-80S ribosome targeted inhibitor anisomycin were… 
Highly Cited
1986
Highly Cited
1986
In Vitro Amoebicidal Testing of Natural Products; Part I. Methodology
in vitro Entamoeba histolytica Cinchona Brucea in vitro 
1985
1985
Studies related to the Robinson transposition reaction
On etudie la formation et la reactivite de dichloro-1,4 butenes-2 thiosubstitues en -2 conduisant a un nouveau sel de bis… 
Highly Cited
1983
Highly Cited
1983
Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.
The effects of the anticancer drugs 4′-demethylepipodophyllotoxin thenylidene β-d-glucoside and 4′-demethylepipodophyllotoxin… 
1982
1982
Phase II trial of bruceantin in metastatic breast carcinoma
A PHASE II EVALUATION OF BRUCEANTIN was carried out in 15 patients with refractory metastatic breast cancer. All patients had… 
1981
1981
Mechanism of eukaryotic protein synthesis inhibition by brusatol.
1981
1981
Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells.
Based on the fact that some known antineoplastic agents possess an ester moiety within their structure, the esters of helenalin… 
1978
1978
In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.
A subline of P388 leukemia resistant to adriamycin (P388/ADR) was developed by exposure to the drug in vivo. Resistance to… 
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