Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.

@article{Gupta1983GeneticBA,
  title={Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.},
  author={Radhey S Gupta},
  journal={Cancer research},
  year={1983},
  volume={43 4},
  pages={1568-74}
}
The effects of the anticancer drugs 4'-demethylepipodophyllotoxin thenylidene /3-o-glucoside and 4'-demethylepipodophyllotoxin ethylidene 0-o-glucoside on the growth and viability of Chinese hamster ovary cells have been examined. Stable mu tants which are from 4to 12-fold more resistant to these drugs (VpmR mutants) are obtained in a single selection step in Chinese hamster ovary cells at a frequency of between 0.2 x 1(T6 and 0.5 x 10~6. However, treatment of cells with the mutagen ethyl… CONTINUE READING

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