Substituted cyclic imides as potential anti-gout agents.
- I. Hall, J. Scoville, D. Reynolds, R. Simlot, P. Duncan
- Chemistry, BiologyLife Science
- 1990
Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica.
- K. Lee, K. Tagahara, J. Lai
- Chemistry, BiologyJournal of Natural Products
- 1 September 1981
Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin…
Mode of action of sesquiterpene lactones as anti-inflammatory agents.
- I. Hall, C. Starnes, K. Lee, T. G. Waddell
- Chemistry, BiologyJournal of Pharmacy and Science
- 1 May 1980
The structure-activity relationships for the stabilization of lysosomal membrane for rat liver cathepsin activity followed the same structural requirement necessary for anti-inflammatory activity; i.e., the alpha-methylene-gamma-lactone moiety contributed the most activity, whereas the beta-unsubstituted cyclopentenone and alpha-epoxycyclopentanone contributed only minor activity.
Antitumor agents LV: Effects of genkwadaphnin and yuanhuacine on nucleic acid synthesis of P-388 lymphocytic leukemia cells.
- I. Hall, R. Kasai, R. Wu, K. Tagahara, K. Lee
- Chemistry, BiologyJournal of Pharmacy and Science
- 1 November 1982
In vivo administration of the diterpene esters at 0.8 mg/kg afforded identical types of effects on purine and DNA synthesis and in addition suppressed histone phosphorylation and reduced the number of surviving tumor cells.
Structure and stereochemistry of (−)-odorinol, an antileukemic diamide from Aglaia odorata☆
- N. Hayashi, K. Lee, I. Hall, A. McPhail, H. Huang
- Chemistry
- 1982
Boron analogs of the .alpha.-amino acids. Synthesis, x-ray crystal structure, and biological activity of ammonia-carboxyborane, the boron analog of glycine
- B. Spielvogel, M. K. Das, A. McPhail, K. Onan, I. Hall
- Chemistry
- 1 September 1980
Cytotoxicity of Metallic Complexes of Furan Oximes in Murine and Human Tissue Cultured Cell Lines
- I. Hall, Christian C. Lee, G. Ibrahim, Mustayeen A. Khan, G. Bouet
- Chemistry, Biology
- 1 November 1999
The cobalt complexes did not demonstrate dramatic cytotoxicity against the growth of tumors derived from solid human tumor lines, and varying the type of metal within the complexes of 2-furaldehyde and furan oximes produces differences in both cytotoxic and mode of action.
Hypolipidemic, anti-obesity, anti-inflammatory, anti-osteoporotic, and anti-neoplastic properties of amine carboxyboranes.
- I. Hall, S. Y. Chen, K. Rajendran, A. Sood, B. Spielvogel, J. Shih
- Biology, ChemistryEnvironmental Health Perspectives
- 1 November 1994
The amine-carboxyborane derivatives were shown to be effective antineoplastic/cytotoxic agents with selective activity against single-cell and solid tumors derived from murine and human leukemias,…
Disposition of an antineoplastic sesquiterpene lactone, [3H]-plenolin, in BDF1 mice.
- A. Grippo, S. Wyrick, K. Lee, R. Shrewsbury, I. Hall
- Biology, MedicinePlanta Medica
- 1 August 1991
The pharmacokinetic data suggested that [3H]-plenolin was secreted in the bile, and radioactivity was sustained in the carcass and skin for 24 days, and the drug did not significantly associate with DNA, RNA, or protein of P388 leukemia or human fibroblast cells.
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
- I. Hall, K. Lee, E. Mar, C. Starnes, T. G. Waddell
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 March 1977
Evidence is presented that sesquiterpene lactones or ketones containing the O=CC=CH2 moiety alkylate the thiol group of reduced glutathione and L-cysteine in vitro, and it is thought that this mechanism of action is responsible for the observed potent in vivo antitumor activity of these agents in the Ehrlich ascites and Walker 256 carcinosarcoma and to a lesser extent in the P388 leukemic screen.
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