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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*
It is found that resveratrol also directly inhibited the activity of COX-2, a phenolic antioxidant found in grapes and other food products, which is likely to be important for understanding the anti-cancer and anti-inflammatory properties of resver atrol.
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
Cancer Chemopreventive Activity of Resveratrol
Evidence indicated that resveratrol selectively suppresses the transcriptional activation of cytochrome P‐450 1A1 and inhibits the formation of carcinogen‐induced preneoplastic lesions in a mouse mammary organ culture model, holding great promise for future development as a chemopreventive agent that may be useful for several disorders.
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
- A. Eggler, Guo-Yu Liu, J. Pezzuto, R. V. van Breemen, A. Mesecar
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 19 July 2005
A model is proposed that should aid in the understanding of Keap1-Nrf2 signaling mechanisms and is tested using a series of ARE inducers, suggesting that the direct disruption model for Keap 1-NRF2 is incorrect.
Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.
- L. Kardono, C. Angerhofer, S. Tsauri, K. Padmawinata, J. Pezzuto, A. Kinghorn
- Biology, ChemistryJournal of natural products
- 1 September 1991
By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia and compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains.
Evaluation of plants used for antimalarial treatment by the Maasai of Kenya.
Evaluation of the antioxidant potential of natural products.
Of these substances, the hydroxystilbenes piceatannol and transresveratrol have thus far been shown to inhibit carcinogen-induced preneoplastic lesion formation in the mouse mammary gland organ culture model.
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.
- K. Bhat, D. Lantvit, K. Christov, R. Mehta, R. Moon, J. Pezzuto
- BiologyCancer Research
- 15 October 2001
The data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer, and exerts mixed estrogen agonist/antagonist activities in some mammary cancer cell lines, but in the presence of E2, resver atrol functions as an antiestrogen.
Human, Rat, and Mouse Metabolism of Resveratrol
AbstractPurpose. Resveratrol, a phenolic phytoalexin occurring in grapes, wine, peanuts, and cranberries, has been reported to have anticarcinogenic, antioxidative, phytoestrogenic, and…