• Publications
  • Influence
The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes.
  • R. Gupta
  • Biology, Medicine
    FEMS microbiology reviews
  • 1 October 2000
TLDR
An unexpected but important aspect of the relationship deduced here is that the main eubacterial phyla are related to each other linearly rather than in a tree-like manner, suggesting that the major evolutionary changes within Bacteria have taken place in a directional manner.
Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species.
  • R. Gupta
  • Biology, Medicine
    Molecular biology and evolution
  • 1 November 1995
TLDR
A global alignment of all available sequences for the 90-kD heat shock protein (Hsp90) family indicates that the cytosolic and the endoplasmic reticulum (ER) resident forms of Hsp90 constitute paralogous gene families which arose by a gene duplication event that took place very early in the evolution of eukaryotic cells.
The branching order and phylogenetic placement of species from completed bacterial genomes, based on conserved indels found in various proteins
  • R. Gupta
  • Biology, Medicine
    International microbiology : the official journal…
  • 20 December 2001
TLDR
The results strongly vindicate the usefulness of the signature sequence approach to understanding phylogeny within the Bacteria and show that it provides a reliable and internally consistent means for the placement of bacterial species into different groups and for determining the relative branching order of the groups.
Adenosine kinase and ribokinase – the RK family of proteins
  • J. Park, R. Gupta
  • Biology, Medicine
    Cellular and Molecular Life Sciences
  • 14 June 2008
TLDR
The topics covered include descriptions of the primary and three-dimensional structures of AK and RK, their phylogenetic relationships, biochemical aspects ofThese enzymes including their reaction mechanisms and ionic requirements, and also work on certain inhibitors of these enzymes.
Evolution of the chaperonin families (HSP60, HSP 10 and TCP‐1) of proteins and the origin of eukaryotic cells
  • R. Gupta
  • Biology, Medicine
    Molecular microbiology
  • 1 January 1995
TLDR
Phylogenetic analysis based on global alignments of Hsp60 and Hsp10 sequences presented here provide some evidence regarding the evolution of mitochondria from a member of the α‐subdivision of Gram‐negative bacteria and chloroplasts from cyanobacterial species, respectively.
The Natural Evolutionary Relationships among Prokaryotes
  • R. Gupta
  • Biology, Medicine
    Critical reviews in microbiology
  • 1 January 2000
TLDR
It is shown that the main eubacterial phyla are related to each other linearly rather than in a tree-like manner, suggesting that the major evolutionary changes within prokaryotes (bacteria) have occurred in a directional manner.
Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.
TLDR
The observed high degree of homology between human P1 and mycobacterial antigen also suggests the possible involvement of this protein in certain autoimmune diseases.
The origin of the eukaryotic cell.
Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells.
TLDR
The subcellular distribution of the 60-kDa heat shock protein (Hsp60) was examined in a variety of mammalian cells and tissues by immunogold electron microscopy employing six different monoclonal and polyclonal antibodies that are specific for Hsp60, providing evidence that at least partial mitochondrial import of HSp60 is necessary for its maturation.
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