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Iridoid Glucosides with Free Radical Scavenging Properties from Fagraea blumei
Four new iridoid glucosides 1–4, named blumeosides A–D, were isolated from the methanolic stem-bark extract of Fagraea blumei G. DON. (Loganiaceae). They were accompanied by the benzyl-alcoholExpand
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Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol,Expand
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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation causedExpand
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Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems.
Curcumin is a natural product widely used as a spice in food. It has been shown to inhibit cyclooxygenase (COX)-1 and -2 and to suppress lipopolysaccharide-induced COX-2 and iNOS gene expression. InExpand
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Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.
Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-beta-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11'-O-beta-D-glucopyranoside (2), were isolated together with theExpand
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The Role of Cyclooxygenase and Lipoxygenase in Cancer Chemoprevention
The involvement of prostaglandins (PGs) and other eicosanoids in the development of human cancer has been known for over two decades. Importantly, an increase in PG synthesis may influence tumorExpand
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Quinone reductase induction as a biomarker for cancer chemoprevention.
Chemoprevention involves the use of natural or synthetic substances to reduce the risk of developing cancer. Strategies for protecting cells from initiation events include decreasing metabolicExpand
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Pleiotropic mechanisms facilitated by resveratrol and its metabolites.
Resveratrol has demonstrated cancer chemopreventive activity in animal models and some clinical trials are underway. In addition, resveratrol was shown to promote cell survival, increase lifespan andExpand
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Natural inhibitors of carcinogenesis.
Previous collaborative work by our group has led to the discovery of several plant isolates and derivatives with activities in in vivo models of cancer chemoprevention, including deguelin,Expand
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