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Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.
Oleanolic acid was identified as an anti-HIV principle from several plants, including Rosa woodsii, Prosopis glandulosa, Phoradendron juniperinum, Syzygium claviflorum, and Hyptis capitata, and Ternstromia gymnanthera.
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
A new triterpenoid named melliferone was isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes and was modified to develop more potent anti-AIDS agents.
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui.
The extract of the roots of Euphorbia kansui demonstrated antileukemic activity against the P-388 lymphocytic leukemia in mice and the selectivity of kansuiphorin A, which inhibits the growth of particular cell types within the disease-oriented human cancer cell line panels, is discussed.
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.
Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.
Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml and the structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) based on spectroscopic evidence.
Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide.
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.
- Y. Kashiwada, G. Nonaka, I. Nishioka, J. Chang, K. Lee
- Medicine, ChemistryJournal of natural products
- 1 August 1992
All of the tannins were found to be inactive (greater than 10 micrograms/ml) against lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of nasopharnyx (KB), and medulloblastoma (TE-671) tumor cells.
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
Two new lignans, interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and…
Bioactive kaurane diterpenoids from Annona glabra.
- F. Chang, P. Yang, J. Lin, K. Lee, Y. C. Wu
- Chemistry, BiologyJournal of Natural Products
- 1 April 1998
Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, which exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid showed significant inhibition of HIV-reverse transcriptase.