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Genomic analysis.
Advances in genomic analysis include improved technology for DNA sequencing, routine use of DNA microarray technology for the analysis of gene expression profiles at the mRNA level and improvedExpand
Correlation of cell body size, axon size, and signal conduction velocity for individually labelled dorsal root ganglion cells in the cat
Measurements of cell body and peripheral and central axon sizes were made for primary sensory neurons outlined by the intracellular injection of HRP and sensory neurons were subdivided into A and C cells on the basis of the conduction velocity of the impulses carried by the processes of these cells. Expand
Purification, molecular cloning, and sequencing of phospholipase C-beta 4.
Results suggest that the brain cDNA encodes PLC-beta 4, which is likely a mammalian homolog of P LC-norpA, which was originally identified in Drosophila eye. Expand
Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.
Oleanolic acid was identified as an anti-HIV principle from several plants, including Rosa woodsii, Prosopis glandulosa, Phoradendron juniperinum, Syzygium claviflorum, and Hyptis capitata, and Ternstromia gymnanthera. Expand
Activation of phospholipase C isozymes by G protein beta gamma subunits.
The results suggest that the extracellular signals that induce the dissociation of G(o) or Gi, the heterotrimeric G proteins abundant in brain, should enhance the hydrolysis of PtdIns 4,5-P2 in brain primarily through activation of PLC-beta 3 (PLC- beta 2 is not detectable in brain). Expand
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.
In vitro assay indicated that these compounds are not inhibitors of HIV-1 reverse transcriptase, whereas they inhibited syncytia formation completely in a concentration range of 20-40 micrograms/mL, however, 3-O-(2',2'-dimethylsuccinyl)-betulinic acid (2) was also found to be an inhibitor of AIDS-induced membrane fusion with an IC100 value of 20 microgramS/mL. Expand
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
Evaluation of anti-HIV activity with eight derivatives of 1 revealed that dihydrobetulinic acid was also a potent inhibitor of HIV replication, and there was no apparent correlation between anti-hIV activity and the inhibition of PKC among these compounds. Expand
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
A new triterpenoid named melliferone was isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes and was modified to develop more potent anti-AIDS agents. Expand
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui.
The extract of the roots of Euphorbia kansui demonstrated antileukemic activity against the P-388 lymphocytic leukemia in mice and the selectivity of kansuiphorin A, which inhibits the growth of particular cell types within the disease-oriented human cancer cell line panels, is discussed. Expand