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brequinar
Known as:
6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid
, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid
, Bipenquinate
A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (4)
Antineoplastic Agents
Biphenyl Compounds
Enzyme Inhibitors
Immunosuppressive Agents
Narrower (2)
DuP 785
NSC 368390
NCIt Antineoplastic Agent Terminology
brequinar sodium
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Artificial intelligence approach fighting COVID-19 with repurposing drugs
Yi-Yu Ke
,
T. Peng
,
+12 authors
C. Chen
Biomedical Journal
2020
Corpus ID: 218644184
Highly Cited
2019
Highly Cited
2019
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Petter I. Andersen
,
Klara Krpina
,
+12 authors
Denis E. Kainov
Viruses
2019
Corpus ID: 204834337
Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization…
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Review
2019
Review
2019
Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer
Joseph T Madak
,
A. Bankhead
,
Christine R Cuthbertson
,
H. Showalter
,
N. Neamati
Pharmacology and Therapeutics
2019
Corpus ID: 53036782
Highly Cited
2017
Highly Cited
2017
Evaluation of anti‐Zika virus activities of broad‐spectrum antivirals and NIH clinical collection compounds using a cell‐based, high‐throughput screen assay
R. S. Adcock
,
Y. Chu
,
Jennifer E. Golden
,
D. Chung
Antiviral Research
2017
Corpus ID: 46754255
2012
2012
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.
Miryam A. Hortua Triana
,
M. Huynh
,
+5 authors
B. Zimmermann
Molecular and biochemical parasitology (Print)
2012
Corpus ID: 26928507
Highly Cited
2001
Highly Cited
2001
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
J. McLean
,
E. Neidhardt
,
T. Grossman
,
L. Hedstrom
Biochemistry
2001
Corpus ID: 20954594
Brequinar and the active metabolite of leflunomide, A77 1726, have been clearly shown to inhibit human dihydroorotate…
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Review
2000
Review
2000
Immunosuppressive drugs: the first 50 years and a glance forward.
A. Allison
Immunopharmacology
2000
Corpus ID: 28836685
Highly Cited
2000
Highly Cited
2000
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Shenping Liu
,
E. A. Neidhardt
,
T. Grossman
,
T. Ocain
,
J. Clardy
Structure
2000
Corpus ID: 22137121
Highly Cited
1998
Highly Cited
1998
Leflunomide Inhibits Pyrimidine de Novo Synthesis in Mitogen-stimulated T-lymphocytes from Healthy Humans*
K. Rückemann
,
L. Fairbanks
,
+4 authors
H. Simmonds
Journal of Biological Chemistry
1998
Corpus ID: 10606564
The mode of action of Leflunomide, an immunomodulatory drug used in rheumatoid arthritis, is debated. This study, using 14C…
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Highly Cited
1985
Highly Cited
1985
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.
Daniel L. Dexter
,
David P. Hesson
,
+8 authors
Martin Forbes
Cancer Research
1985
Corpus ID: 639294
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16…
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