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brequinar

Known as: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, Bipenquinate 
A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby… 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization… 
Highly Cited
2001
Highly Cited
2001
Brequinar and the active metabolite of leflunomide, A77 1726, have been clearly shown to inhibit human dihydroorotate… 
Highly Cited
1998
Highly Cited
1998
The mode of action of Leflunomide, an immunomodulatory drug used in rheumatoid arthritis, is debated. This study, using 14C… 
Highly Cited
1985
Highly Cited
1985
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16…