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brequinar

Known as: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, Bipenquinate 
A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

Antineoplastic AgentsBiphenyl CompoundsEnzyme InhibitorsImmunosuppressive Agents

Narrower (2)

DuP 785NSC 368390
NCIt Antineoplastic Agent Terminologybrequinar sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion
Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide… 
2014
2014
ThermoFMN - a thermofluor assay developed for ligand-screening as an alternative strategy for drug discovery
A tecnica de Termofluor constitui uma importante ferramenta na identificacao de moleculas prototipos a farmacos. No presente… 
2000
2000
Immunosuppression for pediatric cardiac transplantation in the modern era.
1999
1999
Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression.
Human dihydroorotate dehydrogenase (huDHODH) is essential for de novo biosynthesis of pyrimidines and the target of two… 
1998
1998
FLOW CYTOMETRIC (FCM) ANALYSIS OF THE MOLECULAR MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF THE ACTIVE METABOLITE OF LEFLUNOMIDE AND ITS MALONONITRILAMIDE (MNA) ANALOGS IN A NOVEL WHOLE BLOOD ASSAY
Review
1997
Review
1997
Xenobiotic immunosuppressive agents: therapeutic effects in animal models of autoimmune diseases
Abstract An unprecedented arsenal of new xenobiotic immunosuppressive agents has been developed recently. Most of the new… 
1996
1996
Beneficial effect of graft perfusion with anti-T cell receptor monoclonal antibodies on survival of small bowel allografts in rat recipients treated with brequinar alone or in combination with…
In the present experiments, a multimodality regimen was developed that included an anti-T cell receptor R73 monoclonal antibody… 
1996
1996
Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506.
1994
1994
6 New immunosuppressive treatment in transplantation medicine
1990
1990
Effects of brequinar and ciprofloxacin on de novo nucleotide biosynthesis in mouse L1210 leukemia.
Exposure of mouse L1210 leukemia cells to 25 microM brequinar for 4 h results in large accumulations of N-carbamyl-L-aspartate… 
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