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DuP 785

Known as: DUP-785, DUP785 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

brequinarbrequinar sodium

Papers overview

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2018
2018
Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor
  • G. Peters
  • Nucleosides, nucleotides & nucleic acids
  • 2018
  • Corpus ID: 58587302
Abstract DUP-785 (Brequinar sodium) is a potent inhibitor of the mitochondrial dihydroorotate dehydrogenase (DHO-DH), a rate… 
2004
2004
Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)
The mechanism of action of NSC 368390 (DUP-785, 6-fluoro-2-(2′-fluoro-1, 1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid… 
1993
1993
Enhancement of allograft survival by combination RS-61443 and DUP-785 therapy.
Current maintenance immunosuppressive therapy consists of cyclosporine in combination with prednisone and azathioprine… 
1993
1993
Prolongation of allograft and xenograft survival with mycophenolate mofetil (RS-61443) and brequinar sodium (DUP-785).
1992
1992
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Brequinar sodium (DUP-785; Brequinar) is a potent inhibitor of the pyrimidine de novo enzyme dihydroorotate dehydrogenase (DHO-DH… 
Highly Cited
1990
Highly Cited
1990
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… 
1990
1990
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
1990
1990
Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts.
1989
1989
Cellular pharmacology of DUP-785, a new anticancer agent.
DUP-785, a new inhibitor of dihydroorotate dehydrogenase, is currently undergoing clinical evaluation for anticancer activity. We… 
Highly Cited
1985
Highly Cited
1985
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16… 
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