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DuP 785
Known as:
DUP-785
, DUP785
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
brequinar
brequinar sodium
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor
G. Peters
Nucleosides, nucleotides & nucleic acids
2018
Corpus ID: 58587302
Abstract DUP-785 (Brequinar sodium) is a potent inhibitor of the mitochondrial dihydroorotate dehydrogenase (DHO-DH), a rate…
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2004
2004
Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)
G. Peters
,
S. Sharma
,
E. Laurensse
,
H. Pinedo
Investigational New Drugs
2004
Corpus ID: 38549163
The mechanism of action of NSC 368390 (DUP-785, 6-fluoro-2-(2′-fluoro-1, 1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid…
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1993
1993
Enhancement of allograft survival by combination RS-61443 and DUP-785 therapy.
T. Kawamura
,
D. Hullett
,
Y. Suzuki
,
W. Bechstein
,
A. Allison
,
H. Sollinger
Transplantation
1993
Corpus ID: 13157284
Current maintenance immunosuppressive therapy consists of cyclosporine in combination with prednisone and azathioprine…
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1993
1993
Prolongation of allograft and xenograft survival with mycophenolate mofetil (RS-61443) and brequinar sodium (DUP-785).
D. Hullett
,
T. Kawamura
,
Y. Fujino
,
A. Allison
,
H. Sollinger
Transplantation proceedings
1993
Corpus ID: 45316230
1992
1992
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
G. Peters
,
I. Kraal
,
H. Pinedo
British Journal of Cancer
1992
Corpus ID: 15605503
Brequinar sodium (DUP-785; Brequinar) is a potent inhibitor of the pyrimidine de novo enzyme dihydroorotate dehydrogenase (DHO-DH…
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Highly Cited
1990
Highly Cited
1990
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
G. Peters
,
G. Schwartsmann
,
+4 authors
H. Pinedo
Cancer research
1990
Corpus ID: 9798772
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic…
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1990
1990
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
G. Peters
,
J. C. Nadal
,
E. Laurensse
,
E. de Kant
,
H. Pinedo
Biochemical pharmacology
1990
Corpus ID: 1887258
1990
1990
Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts.
B. Braakhuis
,
G. V. van Dongen
,
G. Peters
,
M. van Walsum
,
G. Snow
Cancer letters
1990
Corpus ID: 36942551
1989
1989
Cellular pharmacology of DUP-785, a new anticancer agent.
L. Anderson
,
J. Strong
,
R. Cysyk
Cancer communications
1989
Corpus ID: 25857246
DUP-785, a new inhibitor of dihydroorotate dehydrogenase, is currently undergoing clinical evaluation for anticancer activity. We…
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Highly Cited
1985
Highly Cited
1985
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.
D. Dexter
,
D. Hesson
,
+7 authors
V. Narayanan
Cancer research
1985
Corpus ID: 639294
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16…
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