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DuP 785

Known as: DUP-785, DUP785 
 
National Institutes of Health

Papers overview

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1993
1993
Current maintenance immunosuppressive therapy consists of cyclosporine in combination with prednisone and azathioprine… Expand
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1992
1992
Brequinar sodium (DUP-785; Brequinar) is a potent inhibitor of the pyrimidine de novo enzyme dihydroorotate dehydrogenase (DHO-DH… Expand
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1992
1992
The introduction of cyclosporine into the immunosuppressive armamentarium has revolutionized transplant surgery with significant… Expand
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1990
1990
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… Expand
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1990
1990
Brequinar sodium (DUP-785) is a potent inhibitor of the pyrimidine de novo enzyme, dihydroorotic acid dehydrogenase (DHO-DH). In… Expand
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1990
1990
The effect of Brequinar sodium on the growth of xenografts established from head and neck squamous cell carcinomas (HNSCC) was… Expand
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1989
1989
DUP-785, a new inhibitor of dihydroorotate dehydrogenase, is currently undergoing clinical evaluation for anticancer activity. We… Expand
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1987
1987
The mechanism of action of NSC 368390 (DUP-785, 6-fluoro-2-(2′-fluoro-1, 1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid… Expand
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1985
1985
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16… Expand
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