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brequinar sodium

Known as: Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate 
The sodium salt form of Brequinar. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This… Expand
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
Mitochondrially-bound dihydroorotate dehydrogenase (EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis… Expand
Highly Cited
1996
Highly Cited
1996
The active metabolite of leflunomide. A771726, is a novel immunosuppressive compound that has been shown to be a powerful… Expand
1994
1994
We examined the effect of CsA, mycophenolate mofetil (MM), and Brequinar sodium (BQR) combination therapy on hamster-to-rat… Expand
Review
1993
Review
1993
The preclinical and clinical characterization of Brequinar sodium has demonstrated the potential for the use of this drug as a… Expand
1993
1993
The rigorous median-effect analysis was used to assess the interactions between cyclosporine and drugs that inhibit nucleotide… Expand
Highly Cited
1992
Highly Cited
1992
The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4… Expand
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Highly Cited
1992
Highly Cited
1992
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition of de novo pyrimidine biosynthesis. BQR is capable… Expand
1992
1992
To verify the assumption of a specific and potent drug action on de novo pyrimidine biosynthesis, isolated dihydroorotate… Expand
Highly Cited
1990
Highly Cited
1990
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… Expand
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Highly Cited
1989
Highly Cited
1989
Brequinar sodium is a 4-quinolinecarboxylic acid analogue that inhibits dihydroorotate dehydrogenase and subsequent de novo… Expand