FAQ

brequinar sodium

Known as: Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate 
The sodium salt form of Brequinar. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2016
05101519882016

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2 relations

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DuP 785
brequinar

Related mentions per year

Related mentions per year

1985-2018
19801990200020102020
brequinar sodium
brequinar
DuP 785

Papers overview

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2000
2000
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
Mitochondrially-bound dihydroorotate dehydrogenase (EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis… (More)
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1994
1994
Novel mechanisms of brequinar sodium immunosuppression on T cell activation.
Brequinar sodium (BQR) is a novel immunosuppressive agent that acts by inhibiting the activity of dihydroorotate dehydrogenase… (More)
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1993
1993
Multicenter phase II study of brequinar sodium in patients with advanced breast cancer.
In this study, 34 patients with advanced breast cancer were treated with brequinar sodium: 75% of the patients were… (More)
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1992
1992
Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4… (More)
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1992
1992
The prolongation of concordant hamster-to-rat cardiac xenografts by brequinar sodium.
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition of de novo pyrimidine biosynthesis. The… (More)
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1992
1992
The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat.
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition of de novo pyrimidine biosynthesis. BQR is capable… (More)
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1990
1990
Phase I and pharmacokinetic study of brequinar sodium (NSC 368390).
Brequinar sodium is a quinoline carboxylic acid derivative that has shown antitumor activity in a number of in vivo murine and… (More)
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1990
1990
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… (More)
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1989
1989
Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390).
Brequinar sodium is a 4-quinolinecarboxylic acid analogue that inhibits dihydroorotate dehydrogenase and subsequent de novo… (More)
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1989
1989
Mucocutaneous side effects of Brequinar sodium. A new inhibitor of pyrimidine de novo biosynthesis.
Brequinar sodium (NSC 368390; DUP 785) is a new inhibitor of pyrimidine de novo biosynthesis which has completed Phase I clinical… (More)
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