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brequinar sodium

Known as: Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate 
The sodium salt form of Brequinar. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This… Expand
National Institutes of Health

Papers overview

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2000
2000
Mitochondrially-bound dihydroorotate dehydrogenase (EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis… Expand
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Highly Cited
1996
Highly Cited
1996
The active metabolite of leflunomide. A771726, is a novel immunosuppressive compound that has been shown to be a powerful… Expand
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Review
1993
Review
1993
The preclinical and clinical characterization of Brequinar sodium has demonstrated the potential for the use of this drug as a… Expand
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1993
1993
In this study, 34 patients with advanced breast cancer were treated with brequinar sodium: 75% of the patients were… Expand
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1992
1992
The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4… Expand
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1992
1992
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition of de novo pyrimidine biosynthesis. BQR is capable… Expand
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1992
1992
The immunosuppressive effect of the novel 4-quinoline carboxylic acid derivative Brequinar sodium on the chronic relapsing… Expand
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1990
1990
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… Expand
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1990
1990
Brequinar sodium is a quinoline carboxylic acid derivative that has shown antitumor activity in a number of in vivo murine and… Expand
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1989
1989
Brequinar sodium is a 4-quinolinecarboxylic acid analogue that inhibits dihydroorotate dehydrogenase and subsequent de novo… Expand
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