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brequinar sodium

Known as: Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate 
The sodium salt form of Brequinar. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This… 
National Institutes of Health

Papers overview

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Highly Cited
1996
Highly Cited
1996
The active metabolite of leflunomide. A771726, is a novel immunosuppressive compound that has been shown to be a powerful… 
1994
1994
We examined the effect of CsA, mycophenolate mofetil (MM), and Brequinar sodium (BQR) combination therapy on hamster-to-rat… 
Review
1993
Review
1993
The preclinical and clinical characterization of Brequinar sodium has demonstrated the potential for the use of this drug as a… 
1993
1993
The rigorous median-effect analysis was used to assess the interactions between cyclosporine and drugs that inhibit nucleotide… 
Highly Cited
1992
Highly Cited
1992
The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4… 
Highly Cited
1992
Highly Cited
1992
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition of de novo pyrimidine biosynthesis. BQR is capable… 
Highly Cited
1990
Highly Cited
1990
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… 
Highly Cited
1989
Highly Cited
1989
Brequinar sodium is a 4-quinolinecarboxylic acid analogue that inhibits dihydroorotate dehydrogenase and subsequent de novo…