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Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial
Nanoliposomal irinotecan in combination with fluorouracil and folinic acid extends survival with a manageable safety profile in patients with metastatic pancreatic ductal adenocarcinoma who previously received gemcitabine-based therapy. Expand
Planning cancer control in Latin America and the Caribbean.
- P. Goss, Brittany L. Lee, +69 authors Gustavo S. Azenha
- Medicine, Geography
- The Lancet. Oncology
- 1 April 2013
It is hoped the findings of the Commission and the recommendations will inspire Latin American stakeholders to redouble their efforts to address this increasing cancer burden and to prevent it from worsening and threatening their societies. Expand
Natural products in anticancer therapy.
- A. D. da Rocha, R. Lopes, G. Schwartsmann
- Biology, Medicine
- Current opinion in pharmacology
- 1 August 2001
Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and microorganisms, and anticancer agents derived from microbial sources are found. Expand
Marine organisms as a source of new anticancer agents.
- G. Schwartsmann, A. Brondani da Rocha, R. Berlinck, J. Jimeno
- The Lancet. Oncology
- 1 April 2001
Examples of marine-derived experimental agents that are currently undergoing preclinical and early clinical evaluation are briefly discussed and a summary of the available information on the results of phase I and II trials of agents such as aplidine, ecteinascidin-734 (ET- 734), dolastatin 10 and bryostatin 1 is presented. Expand
Evidence for an association of human papillomavirus infection and colorectal cancer.
- D. Damin, M. C. Caetano, +5 authors C. Alexandre
- European journal of surgical oncology : the…
- 1 June 2007
HPV is present in the colon and rectum of most patients with colorectal adenocarcinoma, suggesting that this virus may be related to the pathogenesis of coloreCTal cancer. Expand
A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patients.
- X. Pivot, P. Koralewski, +5 authors J. Lotz
- Annals of oncology : official journal of the…
- 1 September 2008
XRP6258 was active and well tolerated in this group of MBC patients with taxane-resistant disease, and these results support the further clinical development of this agent. Expand
Extracellular Nucleotides and Nucleosides Induce Proliferation and Increase Nucleoside Transport in Human Glioma Cell Lines
- F. B. Morrone, M. C. Jacques-Silva, +4 authors G. Lenz
- Biology, Medicine
- Journal of Neuro-Oncology
- 1 September 2003
The studies showed that extracellular nucleotides and nucleosides induce proliferation of the studied glioma cells and indicate that the uptake of thymidine and proliferation of gliomas can be induced by purines and pyrimidines via both P1 and P2 purinoceptors. Expand
Breast cancer in South America: challenges to improve early detection and medical management of a public health problem.
- G. Schwartsmann
- Journal of clinical oncology : official journal…
- 15 September 2001
The available data on the incidence and mortality rates of breast cancer in South America, as well as the published literature on risk factors and the limitations of early detection of the disease, are discussed. Expand
Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus
It is concluded that memory modulation by hippocampal GRPRs is mediated by the PKC, MAPK, and PKA pathways, supporting the view that the GRPR is a target for the development of cognitive enhancers for dementia. Expand
Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.
Perillyl alcohol is well tolerated and regression of tumor size in some patients is suggestive of antitumor activity, and POH intranasal delivery is discussed as a potential adjuvant therapeutic strategy for patients with malignant gliomas. Expand