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antalarmin

Known as: N-butyl-N-ethyl-(2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)amine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrimidinesPyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases--the 10-year update.
Highly Cited
2010
Highly Cited
2010
Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation
Highly Cited
2008
Highly Cited
2008
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Stress is a complex human experience having both positive and negative motivational properties. When chronic and uncontrollable… 
Highly Cited
2007
Highly Cited
2007
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
Rationale and objectivesYohimbine is an alpha-2 adrenoreceptor antagonist that provokes stress- and anxiety-like responses in… 
Highly Cited
2005
Highly Cited
2005
Corticosterone implants to the amygdala and type 1 CRH receptor regulation: Effects on behavior and colonic sensitivity
Review
2002
Review
2002
Neuroendocrine aspects of the response to stress.
Disruptions in homeostasis (ie, stress) place demands on the body that are met by the activation of 2 systems, the hypothalamic… 
Highly Cited
2000
Highly Cited
2000
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Highly Cited
2000
Highly Cited
2000
Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates.
We evaluated the effects of the lipophilic nonpeptide corticotropin-releasing hormone (CRH) type 1 receptor antagonist antalarmin… 
Highly Cited
1998
Highly Cited
1998
The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress *
The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it’s… 
Highly Cited
1996
Highly Cited
1996
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary ACTH release and… 
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