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Dietary factors and low-grade inflammation in relation to overweight and obesity
- P. Calder, N. Ahluwalia, B. Winklhofer-Roob
- Medicine, BiologyBritish Journal of Nutrition
- 1 December 2011
Potential mechanisms are described and research gaps, which limit the understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Signalling networks regulating cyclooxygenase-2.
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
- A. Arranz, Christina Doxaki, C. Tsatsanis
- BiologyProceedings of the National Academy of Sciences
- 30 May 2012
It is reported that Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype, which was more resistant to LPS-induced endotoxin shock and to dextran sulfate sodium (DSS)-induced colitis than wild-type mice, whereasAkt1−/− mice were more sensitive.
Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli.
Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice
Akt2 suppression and miR-146a induction promote the M2 macrophage phenotype, resulting in amelioration of acid-induced lung injury, which may be deleterious in septic ARDS because of impaired bacterial clearance.
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins.
- I. Charalampopoulos, C. Tsatsanis, A. Gravanis
- BiologyProceedings of the National Academy of Sciences…
- 25 May 2004
The findings suggest that decline of DHEA(S) and Allo during aging or stress may leave the adrenal medulla unprotected against proapoptotic challenges.
Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-11
The data suggest that CRF peptides play an important role on macrophage function, and augment the effect of LPS by inducing Tlr4 gene expression, through CRF2, via activation of the transcription factors PU.1 and AP-1.
Vitamin D and Exercise Performance in Professional Soccer Players
It is suggested that vitamin D levels are associated with the ergometric evaluation of muscle strength, as expressed by SJ and CMJ, sprinting capacity, and VO2max in professional soccer players, irrespective the levels of performance.
Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery.
- A. Sasaki, O. Shinkawa, K. Yoshinaga
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 February 1987
We previously reported that immunoreactive corticotropin-releasing hormone (CRH) is present in human placenta and third trimester maternal plasma, and that such material is very similar to rat CRH…