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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
- J. Bravo, P. Forsythe, J. Cryan
- Biology, PsychologyProceedings of the National Academy of Sciences
- 29 August 2011
Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis.
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
- M. Claesson, S. Cusack, P. O’Toole
- BiologyProceedings of the National Academy of Sciences
- 22 June 2010
It is concluded that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability.
Microbiota and neurodevelopmental windows: implications for brain disorders.
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
Psychobiotics: A Novel Class of Psychotropic
Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.