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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
TLDR
Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis. Expand
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
TLDR
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders. Expand
Microbiota and neurodevelopmental windows: implications for brain disorders.
TLDR
The concept of parallel and interacting microbial-neural critical windows opens new avenues for developing novel microbiota-modulating based therapeutic interventions in early life to combat neurodevelopmental deficits and brain disorders. Expand
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
TLDR
It is concluded that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. Expand
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
TLDR
Fecal microbiota transplantation from depressed patients to microbiota-depleted rats can induce behavioural and physiological features characteristic of depression in the recipient animals, including anhedonia and anxiety-like behaviours, as well as alterations in tryptophan metabolism, which suggests that the gut microbiota may play a causal role in the development of features of depression. Expand
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
TLDR
Findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered. Expand
Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test
TLDR
It is suggested that multiple readouts are necessary to derive maximum information and this strategy will enhance the understanding of the psychobiology of stress and provide the means to assess novel therapeutic agents. Expand
Psychobiotics: A Novel Class of Psychotropic
TLDR
A psychobiotic is defined as a live organism that, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness and has a capacity to reduce hypothalamic-pituitary-adrenal axis activity. Expand
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
TLDR
The attenuation of pro-inflammatory immune responses, and the elevation of the serotonergic precursor, tryptophan by bifidobacteria treatment, provides encouraging evidence in support of the proposition that this probiotic may possess antidepressant properties. Expand
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