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Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes.
The binding parameters of radiolabeled DAMGO (mu), DPDPE and pCl-DPDPE (delta) and 5 alpha, 7 alpha, 8 beta-N-methyl-N-[7-(1- pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl]benzeneacetamide (also known asExpand
Benzodiazepines: use, abuse, and consequences.
Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.
The results presented show that the stable expression of the rat mu opioid receptor in C6 cells provides an effective tool to examine opioid receptor signal transduction mechanisms and evaluate the activity of novel opioids at the mu receptor. Expand
Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve. Expand
Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys.
The present results suggest that BZP has abuse liability of the amphetamine type, but that such effects are not shared by TFMPP. Expand
Patterns of Nicotinic Receptor Antagonism: Nicotine Discrimination Studies
It is suggested that small doses of nicotine produce their stimulus effects via α4β2* nicotine receptors, whereas larger doses of Nicotine recruit additional nicotine receptor subtypes, as revealed by drug discrimination assays in rats. Expand
The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors.
In substitution tests, compounds that shared antagonistic action at 5-hydroxytryptamine (5-HT)1C and 5-HT2 receptors produced discriminative stimulus effects similar to clozapine: cyproheptadine, metergoline, mianserin, pizotifen and fluperlapine. Expand
Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
A large degree of genetically‐determined variability in sensitivity to painful stimuli is demonstrated, and inherent differences in sensitive stimuli may be responsible, in part, for individual differences in the potency of morphine's antinociceptive effects. Expand
Interaction of 5-HT2A and 5-HT2C Receptors in R(−)-2,5-Dimethoxy-4-iodoamphetamine-Elicited Head Twitch Behavior in Mice
Results of these experiments provide strong evidence that DOI-elicited head-twitch behavior is a 5-HT2A agonist-mediated effect, with subsequent inhibition of head- twitch behavior being driven by competing 5- HT2C agonist activity. Expand
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors. Expand