alitretinoin

Known as: Alitretinoína, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 9-cis-RA 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities… (More)
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (5)

ALRT1057BAL4079LGD1057Panretin
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Broader (2)

Antineoplastic AgentsTretinoin
ApoptosisDermatologic disordersHypersensitivityInhibition of Cell Proliferation
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo…
BACKGROUND Patients with severe chronic hand eczema (CHE) refractory to topical corticosteroids currently have limited treatment… (More)
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Review
2002
Review
2002
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.
The nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic… (More)
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Highly Cited
2001
Highly Cited
2001
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
In an attempt to identify transcription factors which activate sterol-regulatory element-binding protein 1c (SREBP-1c… (More)
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Review
2000
Review
2000
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.
Vitamin A (retinol) and provitamin A (beta-carotene) are metabolized to specific retinoid derivatives which function in either… (More)
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Highly Cited
1995
Highly Cited
1995
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an… (More)
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Highly Cited
1995
Highly Cited
1995
PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.
Phosphoenolpyruvate carboxykinase (PEPCK) is expressed at high levels in liver, kidney, and adipose tissue. This enzyme catalyzes… (More)
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Highly Cited
1995
Highly Cited
1995
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.
In addition to its role as a 9-cis retinoic acid receptor, RXR has an important role in the regulation of multiple hormonal… (More)
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Highly Cited
1994
Highly Cited
1994
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Previously, we have isolated and characterized an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that… (More)
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Review
1993
Review
1993
Acute promyelocytic leukemia.
Perhaps the most important advance in this field is not the specific actions of all-trans-retinoic acid in acute promyelocytic… (More)
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Highly Cited
1992
Highly Cited
1992
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems… (More)
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