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alitretinoin

Known as: Alitretinoína, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 9-cis-RA 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (5)

ALRT1057BAL4079LGD1057Panretin

Broader (2)

Antineoplastic AgentsTretinoin
ApoptosisDermatologic disordersHypersensitivityInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry.
Receptors for retinoic acid act as ligand activated transcription factors. The three-dimensional structure of the retinoid X… 
Highly Cited
2002
Highly Cited
2002
Mechanism of protection induced by vitamin A in falciparum malaria
Highly Cited
2001
Highly Cited
2001
2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.
Female transgenic mice that express SV40 T/t antigens under the regulatory control of the rat C3(1) gene spontaneously develop… 
Highly Cited
1998
Highly Cited
1998
Induction of apoptosis in MCF-7 breast carcinoma cell line by RAR and RXR selective retinoids.
Induction of apoptosis in MCF-7 breast carcinoma cell line by various retinoids was measured by cytofluorimetry and DNA… 
Review
1998
Review
1998
Therapy of acute promyelocytic leukemia: all-trans retinoic acid and beyond.
Acute promyelocytic leukemia (APL) is the most potentially curable subtype of acute myeloid leukemia (AML). APL is highly… 
Highly Cited
1995
Highly Cited
1995
Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.
Both anchorage-dependent growth and anchorage-independent growth of the estrogen receptor-positive mammary carcinoma cell line… 
Highly Cited
1994
Highly Cited
1994
Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.
1994
1994
The expression of retinoid X receptor genes is regulated by all-trans- and 9-cis-retinoic acid in F9 teratocarcinoma cells.
Two classes of nuclear receptors for retinoic acid (RA) have been identified--retinoic acid receptor (RAR) and retinoid x… 
Highly Cited
1993
Highly Cited
1993
Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct… 
Highly Cited
1993
Highly Cited
1993
9-cis-retinoic acid, a potent inducer of digit pattern duplications in the chick wing bud.
The effects of retinoids are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid-X-receptors… 
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