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alitretinoin

Known as: Alitretinoína, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 9-cis-RA 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (5)

ALRT1057BAL4079LGD1057Panretin

Broader (2)

Antineoplastic AgentsTretinoin
ApoptosisDermatologic disordersHypersensitivityInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial.
BACKGROUND Loss of retinoic acid receptor beta (RAR-beta) expression in the bronchial epithelium is considered a biomarker of… 
Highly Cited
2003
Highly Cited
2003
Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice
Highly Cited
2002
Highly Cited
2002
Mechanism of protection induced by vitamin A in falciparum malaria
Highly Cited
2001
Highly Cited
2001
The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation.
Ultraspiracle (USP) is the invertebrate homologue of the mammalian retinoid X receptor (RXR). RXR plays a uniquely important role… 
Highly Cited
1999
Highly Cited
1999
Up‐regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator‐activated receptor ligands and 9‐cis retinoic acid in L6 myotubes
Highly Cited
1997
Highly Cited
1997
Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro
Transfection and transgenic mouse experiments supported an oncogenic role for cyclin D1 in breast cancer. We recently reported… 
Highly Cited
1997
Highly Cited
1997
Identification and Characterization of a Stereospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation
All-trans- and 9-cis-retinoic acid are active retinoids for regulating expression of retinoid responsive genes, serving as… 
Highly Cited
1995
Highly Cited
1995
Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.
Both anchorage-dependent growth and anchorage-independent growth of the estrogen receptor-positive mammary carcinoma cell line… 
Highly Cited
1994
Highly Cited
1994
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
all-trans-Retinoic acid is known to bind to the retinoic acid receptors (RARs) resulting in an increase in their transcriptional… 
Highly Cited
1993
Highly Cited
1993
Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct… 
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