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alitretinoin

Known as: Alitretinoína, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 9-cis-RA 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (5)

ALRT1057BAL4079LGD1057Panretin

Broader (2)

Antineoplastic AgentsTretinoin
ApoptosisDermatologic disordersHypersensitivityInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods.
Organotin compounds released from antifouling paints, such as tributyltin (TBT) and triphenyltin (TPT), are potent inducers of… 
Highly Cited
2001
Highly Cited
2001
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.
The gamma isoform of the peroxisome proliferator-activated receptor (PPARgamma) is a nuclear receptor that regulates adipocyte… 
Review
1998
Review
1998
Orphan nuclear receptors--new ligands and new possibilities.
Nuclear hormone receptors comprise a large superfamily of ligand-modulated transcription factors that, in part, mediate response… 
Highly Cited
1997
Highly Cited
1997
DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements
The three subtypes of the peroxisome proliferator-activated receptors (PPARα, β/δ, and γ) form heterodimers with the 9-cis… 
Highly Cited
1995
Highly Cited
1995
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an… 
Highly Cited
1995
Highly Cited
1995
Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids
Activation of T cell hybridomas induces a G1/S cell cycle block and apoptosis. We isolated a variant of the 2B4.11 T cell… 
Highly Cited
1995
Highly Cited
1995
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor.
We have cloned a member of the nuclear receptor superfamily. The cDNA was isolated from a rat liver library and encodes a protein… 
Highly Cited
1995
Highly Cited
1995
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription.
We have identified a peroxisome proliferator response element (PPRE) approx. 4300 nucleotide upstream of the rat cytochrome P-450… 
Highly Cited
1994
Highly Cited
1994
Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.
The cDNA for a member of the nuclear receptor family was cloned and named ubiquitous receptor (UR), since UR protein and mRNA are… 
Highly Cited
1992
Highly Cited
1992
Retinoids selective for retinoid X receptor response pathways.
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are… 
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