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alitretinoin
Known as:
Alitretinoína
, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
, 9-cis-RA
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An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities…
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National Institutes of Health
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Related topics
Related topics
20 relations
Narrower (5)
ALRT1057
BAL4079
LGD1057
Panretin
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Broader (2)
Antineoplastic Agents
Tretinoin
Apoptosis
Dermatologic disorders
Hypersensitivity
Inhibition of Cell Proliferation
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
P. Costet
,
Y. Luo
,
N. Wang
,
A. Tall
Journal of Biological Chemistry
2000
Corpus ID: 45249852
Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages…
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Review
1997
Review
1997
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group.
A. Lowenfels
,
P. Maisonneuve
,
+4 authors
D. Whitcomb
Journal of the National Cancer Institute
1997
Corpus ID: 7899730
BACKGROUND Hereditary pancreatitis is an autosomal-dominant disease, with a variable expression and an estimated penetrance of 80…
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Highly Cited
1996
Highly Cited
1996
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
K. Schoonjans
,
J. Peinado-Onsurbe
,
+5 authors
J. Auwerx
EMBO Journal
1996
Corpus ID: 21106372
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of fibrates, thiazolidinediones and…
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Highly Cited
1995
Highly Cited
1995
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
P. J. Willy
,
K. Umesono
,
E. Ong
,
R. Evans
,
R. Heyman
,
D. Mangelsdorf
Genes & Development
1995
Corpus ID: 20354329
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the…
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Highly Cited
1995
Highly Cited
1995
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
W. Bourguet
,
M. Ruff
,
P. Chambon
,
H. Gronemeyer
,
D. Moras
Nature
1995
Corpus ID: 4371873
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an…
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Highly Cited
1994
Highly Cited
1994
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
P. Tontonoz
,
E. Hu
,
R. Graves
,
A. Budavari
,
B. Spiegelman
Genes & Development
1994
Corpus ID: 39286082
Previously, we have isolated and characterized an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that…
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Highly Cited
1992
Highly Cited
1992
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
R. Heyman
,
D. Mangelsdorf
,
+4 authors
C. Thaller
Cell
1992
Corpus ID: 39338234
Review
1992
Review
1992
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
S. Kliewer
,
K. Umesono
,
D. Noonan
,
R. Heyman
,
R. Evans
Nature
1992
Corpus ID: 8458567
PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the…
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Highly Cited
1992
Highly Cited
1992
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
A. Levin
,
L. Sturzenbecker
,
+8 authors
J. Grippo
Nature
1992
Corpus ID: 2298366
VITAMIN A (retinol) and its natural derivatives are required for many physiological processes1–3. The activity of retinoids is…
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Highly Cited
1992
Highly Cited
1992
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
D. Mangelsdorf
,
U. Borgmeyer
,
+5 authors
R. Evans
Genes & Development
1992
Corpus ID: 29092154
An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems…
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