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alitretinoin

Known as: Alitretinoína, (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 9-cis-RA 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (5)

ALRT1057BAL4079LGD1057Panretin

Broader (2)

Antineoplastic AgentsTretinoin
ApoptosisDermatologic disordersHypersensitivityInhibition of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages… 
Review
1997
Review
1997
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group.
BACKGROUND Hereditary pancreatitis is an autosomal-dominant disease, with a variable expression and an estimated penetrance of 80… 
Highly Cited
1996
Highly Cited
1996
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of fibrates, thiazolidinediones and… 
Highly Cited
1995
Highly Cited
1995
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the… 
Highly Cited
1995
Highly Cited
1995
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an… 
Highly Cited
1994
Highly Cited
1994
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Previously, we have isolated and characterized an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that… 
Highly Cited
1992
Highly Cited
1992
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Review
1992
Review
1992
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the… 
Highly Cited
1992
Highly Cited
1992
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
VITAMIN A (retinol) and its natural derivatives are required for many physiological processes1–3. The activity of retinoids is… 
Highly Cited
1992
Highly Cited
1992
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems… 
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