Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.

@article{Kizaki1993EffectsON,
  title={Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.},
  author={Miho Kizaki and Yasuhiro Ikeda and Ryuji Tanosaki and Hiroshi Nakajima and Minoru Morikawa and Araci M Sakashita and H. Phillip Koeffler},
  journal={Blood},
  year={1993},
  volume={82 12},
  pages={
          3592-9
        }
}
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct families of transcriptional factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). A stereoisomer of retinoic acid, 9-cis-retinoic acid, is a high-affinity ligand for RXR and binds efficiently to RAR. In contrast, all-trans-retinoic acid interacts 40-fold less efficiently with RXR as compared with RAR. To clarify the biologic role of retinoic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

Cell Cycle Inhibitors in Cancer Therapy

  • Cancer Drug Discovery and Development
  • 2003
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Clinical pharmacology of oral all - trans retinoic acid in patients with acute promyelocytic leuke

SA Kliewer, K Umesono, DJ Mangelsdorf, RM Evans
  • Cancer Res
  • 1992

Similar Papers