• Publications
  • Influence
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
TLDR
LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease by retaining key features of HSCs and having a retinoid phenotype typical of stellate cells. Expand
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.
TLDR
It is shown that glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) plays a critical role in the lipolytic processing of chylomicrons in capillaries. Expand
Vitamin A Metabolism: An Update
TLDR
This review will focus on recent advances for understanding retinoid metabolism that have taken place in the last ten to fifteen years. Expand
Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein
TLDR
RBP is needed for normal vision in young animals and for retinol mobilization in times of insufficient dietary intake, but is otherwise dispensable for the delivery ofretinol to tissues. Expand
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.
TLDR
HSC-T6 cells display the same retinoid-related phenotype as primary stellate cells in culture and will be a useful tool for study of hepatic retinoids storage and metabolism. Expand
Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis*
TLDR
A direct functional role for both HSL and ATGL in hepatic lipid homeostasis is suggested and these enzymes are identified as potential therapeutic targets for ameliorating hepatic steatosis associated with insulin resistance and obesity. Expand
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.
TLDR
Information suggests that HSC lipid droplets are specialized organelles for hepatic retinoid storage and that loss of HSC cholesterol droplets may contribute to the development of hepatic disease. Expand
Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT)*
TLDR
Examination by electron microscopy reveals a striking total absence of large lipid-containing droplets that normally store hepatic retinoid within the hepatic stellate cells of Lrat-/- mice, which suggests the existence of a physiologically significant acyl-CoA:retinol acyltransferase. Expand
Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.
TLDR
It is determined that the severity of glucose intolerance and insulin resistance that mice develop when fed a HFD is in part a consequence of osteoblast-dependent insulin resistance, and data indicate that insulin resistance develops in bone as the result of lipotoxicity-associated loss of insulin receptors. Expand
Hand-grip muscle strength, lean body mass, and plasma proteins as markers of nutritional status in patients with chronic renal failure close to start of dialysis therapy.
TLDR
The present study shows a high prevalence of malnutrition in predialysis patients withCRF and suggests that HGS is a reliable, inexpensive, and easy-to-perform nutritional parameter in patients with CRF. Expand
...
1
2
3
4
5
...