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Essential role of Plzf in maintenance of spermatogonial stem cells
Results identify Plzf as a spermatogonia-specific transcription factor in the testis that is required to regulate self-renewal and maintenance of the stem cell pool.
Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation
The conserved transcriptome in human and rodent male gametogenesis
Genes known to be important for sexual reproduction are significantly enriched among differentially expressed core loci and a smaller group of conserved genes not detected in 17 nontesticular somatic tissues, correlating transcriptional activation and essential function in the male germ line.
Cyclin-dependent kinases: a family portrait
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific…
Cyclin A1 is required for meiosis in the male mouse
- Dong Liu, M. Matzuk, W. Sung, Qiuxia Guo, Pei Wang, D. Wolgemuth
- BiologyNature Genetics
- 1 December 1998
Meiosis arrest in Ccna1–/– males was associated with increased germ cell apoptosis, desynapsis abnormalities and reduction of Cdc2 kinase activation at the end of meiotic prophase, indicating cyclin A1 is essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins.
The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase
Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.
- G. Horan, R. Ramírez-Solis, M. Featherstone, D. Wolgemuth, A. Bradley, R. Behringer
- BiologyGenes & Development
- 1 July 1995
A certain degree of functional redundancy among paralogous genes in specifying regional identity is suggested among single mutant phenotypes alone, such that multiple mutations in these genes result in transformations of vertebrae that are not at their anterior limit of expression.
Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality
These investigations establish Mrad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development.
A distinct cyclin A is expressed in germ cells in the mouse.
The existence of two A-type cyclins in the mouse is demonstrated and data indicate that mammalian germ cells contain cyclin A1-dependent kinases that either act as a substitute for, or in addition to, the Cyclin A2-dependent Kinases characterised in somatic tissues.