Skip to search formSkip to main contentSkip to account menu

afimoxifene

Known as: 4-OHT, para-hydroxytamoxifen, 4OH-tamoxifen 
A form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Antineoplastic AgentsEstrogen AntagonistsSelective Estrogen Receptor ModulatorsTamoxifen
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast…
De novo insensitivity and acquired resistance to the selective oestrogen receptor modulator tamoxifen and the pure anti-oestrogen… 
Highly Cited
2004
Highly Cited
2004
Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion.
Highly Cited
2003
Highly Cited
2003
Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.
Estrogen receptor (ER)alpha and -beta interact with a variety of coactivator proteins, most notably members of the steroid… 
Highly Cited
2002
Highly Cited
2002
AR and ER interaction with a p21-activated kinase (PAK6).
A human protein termed p21-activated kinase 6 (PAK6), based on homology to the PAK family of serine/threonine kinases, was cloned… 
Highly Cited
1999
Highly Cited
1999
Estrogen Receptor Reduces CYP1A1 Induction in Cultured Human Endometrial Cells*
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exerts its toxic action via the aryl hydrocarbon (Ah) receptor, which induces a… 
Highly Cited
1996
Highly Cited
1996
Modulation of c-Myc activity and apoptosis in vivo.
We have developed an animal tumor model system to study the effects of c-Myc activation on apoptosis induction in vivo. Tumors… 
Highly Cited
1995
Highly Cited
1995
In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone‐3‐O‐sulphamate
Many tumours in endocrine‐sensitive tissues, such as the breast and endometrium, are hormone‐dependent and the hydrolysis of… 
Highly Cited
1990
Highly Cited
1990
Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide.
The antiestrogen tamoxifen and the aromatase inhibitor aminoglutethimide show similar response rates when used in the endocrine… 
Highly Cited
1989
Highly Cited
1989
Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells.
The effects of tamoxifen, three of its in vivo metabolites and 3-hydroxytamoxifen on cellular proliferation and the induction of… 
Highly Cited
1985
Highly Cited
1985
Hydroxy derivatives of tamoxifen.
In the exploration of the structural features that affect the RBA (binding affinity for the estrogen receptor of rat uterus… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)