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Selective Estrogen Receptor Modulators

Known as: Selective Estrogen Receptor Modifying Agents, selective estrogen receptor modulator (SERM), Selective Estrogen Receptor Modulator 
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an… 
National Institutes of Health

Related topics

Related topics

19 relations
Bone Density Conservation AgentsEstrogen Agonist/Antagonist [EPC]Estrogen AntagonistsIn Blood

Narrower (10)

ClomipheneEnclomipheneLY 117018Raloxifene

Broader (1)

Hormones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
ERβ-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
Highly Cited
2005
Highly Cited
2005
Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women.
Highly Cited
2005
Highly Cited
2005
Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.
The 17beta-estradiol (E2) receptor isoforms [estrogen receptor (ER) alpha and ERbeta] bind E2 and selective ER modulators (SERMs… 
2004
2004
Cardiovascular effects of raloxifene: the arterial and venous systems.
Review
2003
Review
2003
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients
Highly Cited
2003
Highly Cited
2003
Modulation of Estrogen Receptor α Function and Stability by Tamoxifen and a Critical Amino Acid (Asp-538) in Helix 12*
Estrogen receptor α (ER) is a ligand-activated transcription factor implicated in breast cancer growth. Selective estrogen… 
Review
2003
Review
2003
Adaptive hypersensitivity to estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention.
Clinical observations suggest that human breast tumors can adapt to endocrine therapy by developing hypersensitivity to estradiol… 
2002
2002
Biomedicine. Defining the "S" in SERMs.
Review
2001
Review
2001
The Past, Present, and Future of Selective Estrogen Receptor Modulation
Abstract: The recognition of selective estrogen receptor modulation in the mid‐1980s provided a unique opportunity to develop… 
Review
1999
Review
1999
Selective estrogen receptor modulators: tissue selectivity and differential uterine effects.
Selective estrogen receptor modulators (SERMs) are compounds that bind to estrogen receptors and produce estrogen-like (agonist… 
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