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Selective Estrogen Receptor Modulators
Known as:
Selective Estrogen Receptor Modifying Agents
, selective estrogen receptor modulator (SERM)
, Selective Estrogen Receptor Modulator
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A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an…
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National Institutes of Health
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Related topics
Related topics
19 relations
Bone Density Conservation Agents
Estrogen Agonist/Antagonist [EPC]
Estrogen Antagonists
In Blood
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Narrower (10)
Clomiphene
Enclomiphene
LY 117018
Raloxifene
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Broader (1)
Hormones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
ERβ-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
M. Rhodes
,
C. Frye
Neurobiology of Learning and Memory
2006
Corpus ID: 46844160
Highly Cited
2005
Highly Cited
2005
Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women.
G. Boivin
,
S. Vedi
,
D. Purdie
,
J. Compston
,
P. Meunier
Bone
2005
Corpus ID: 22617882
Highly Cited
2005
Highly Cited
2005
Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.
D. Monroe
,
F. Secreto
,
M. Subramaniam
,
B. Getz
,
S. Khosla
,
T. Spelsberg
Molecular Endocrinology
2005
Corpus ID: 34252243
The 17beta-estradiol (E2) receptor isoforms [estrogen receptor (ER) alpha and ERbeta] bind E2 and selective ER modulators (SERMs…
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2004
2004
Cardiovascular effects of raloxifene: the arterial and venous systems.
R. Blumenthal
,
B. Baranowski
,
S. Dowsett
American Heart Journal
2004
Corpus ID: 41442900
Review
2003
Review
2003
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients
T. Nakata
,
S. Takashima
,
+7 authors
T. Saeki
Journal of Steroid Biochemistry and Molecular…
2003
Corpus ID: 10978205
Highly Cited
2003
Highly Cited
2003
Modulation of Estrogen Receptor α Function and Stability by Tamoxifen and a Critical Amino Acid (Asp-538) in Helix 12*
S. Pearce
,
Hong Liu
,
V. Jordan
Journal of Biological Chemistry
2003
Corpus ID: 25739403
Estrogen receptor α (ER) is a ligand-activated transcription factor implicated in breast cancer growth. Selective estrogen…
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Review
2003
Review
2003
Adaptive hypersensitivity to estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention.
R. Santen
,
R. Song
,
+5 authors
L. M. Berstein
Endocrine-Related Cancer
2003
Corpus ID: 28615371
Clinical observations suggest that human breast tumors can adapt to endocrine therapy by developing hypersensitivity to estradiol…
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2002
2002
Biomedicine. Defining the "S" in SERMs.
B. Katzenellenbogen
,
J. Katzenellenbogen
Science
2002
Corpus ID: 25536256
Review
2001
Review
2001
The Past, Present, and Future of Selective Estrogen Receptor Modulation
V. Jordan
Annals of the New York Academy of Sciences
2001
Corpus ID: 38739347
Abstract: The recognition of selective estrogen receptor modulation in the mid‐1980s provided a unique opportunity to develop…
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Review
1999
Review
1999
Selective estrogen receptor modulators: tissue selectivity and differential uterine effects.
S. Silfen
,
A. Ciaccia
,
H. Bryant
Climacteric
1999
Corpus ID: 8569735
Selective estrogen receptor modulators (SERMs) are compounds that bind to estrogen receptors and produce estrogen-like (agonist…
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