Selective Estrogen Receptor Modulators

Known as: Selective Estrogen Receptor Modifying Agents, selective estrogen receptor modulator (SERM), Selective Estrogen Receptor Modulator 
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an… (More)
National Institutes of Health

Related topics

Related topics

19 relations
Bone Density Conservation AgentsEstrogen Agonist/Antagonist [EPC]Estrogen AntagonistsIn Blood
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Narrower (10)

ClomipheneEnclomipheneLY 117018Raloxifene
(More)

Broader (1)

Hormones

Papers overview

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Highly Cited
2013
Highly Cited
2013
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.
Ebola viruses remain a substantial threat to both civilian and military populations as bioweapons, during sporadic outbreaks, and… (More)
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Review
2008
Review
2008
Selective estrogen receptor modulators: an update on recent clinical findings.
Recent clinical data on selective estrogen receptor modulators (SERMs) have provided the basis for reassessment of the SERM… (More)
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Highly Cited
2008
Highly Cited
2008
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Selective estrogen receptor (ER) modulators (SERMs) are ER ligands whose relative agonist/antagonist activities vary in a cell… (More)
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Review
2007
Review
2007
Selective estrogen-receptor modulators and antihormonal resistance in breast cancer.
Selective estrogen-receptor (ER) modulators (SERMs) are synthetic nonsteroidal compounds that switch on and switch off target… (More)
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Highly Cited
2005
Highly Cited
2005
ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats
17β-Estradiol (E2) may influence anxiety behavior; however, its effects and mechanisms are not well understood. To determine… (More)
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Highly Cited
2004
Highly Cited
2004
Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.
Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the treatment of many estrogen receptor… (More)
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Review
2004
Review
2004
Selective estrogen receptor modulation: concept and consequences in cancer.
Extended exposure to the selective estrogen receptor modulators (SERMs) such as raloxifene to prevent osteoporosis and tamoxifen… (More)
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Review
2000
Review
2000
Selective estrogen receptor modulators: structure, function, and clinical use.
The sex hormone estrogen is important for many physiologic processes. Prolonged stimulation of breast ductal epithelium by… (More)
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Review
2000
Review
2000
Molecular mechanisms of selective estrogen receptor modulator (SERM) action.
In females, estrogens play a key role in reproduction and have beneficial effects on the skeletal, cardiovascular, and central… (More)
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Highly Cited
1998
Highly Cited
1998
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Ligand-dependent activation of transcription by nuclear receptors (NRs) is mediated by interactions with coactivators. Receptor… (More)
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