• Publications
  • Influence
Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
Learning and memory processes may be influenced by fluctuations in steroid hormones, such as estrogens and progestins. In this study, we have used an animal model to investigate the effects ofExpand
  • 221
  • 24
Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP
Sex differences and estrous cycle variations in anxiolytic-like behaviors and progestin concentrations were examined. Proestrous (n=22), estrous (n=19), diestrous (n=20), and male (n=18) Long–EvansExpand
  • 379
  • 13
Antidepressant effects of ERβ-selective estrogen receptor modulators in the forced swim test
Estradiol (E2) may influence depressive symptomology of women and decrease depressive behavior among rodents. The mechanism(s) for E2's antidepressant effects are not well understood. To determineExpand
  • 156
  • 8
Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test.
Estradiol (E2) may influence depressive symptomology of women and decrease depressive behavior among rodents. The mechanism(s) for E2's antidepressant effects are not well understood. To determineExpand
  • 65
  • 7
ERβ-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
  • M. Rhodes, C. Frye
  • Medicine, Psychology
  • Neurobiology of Learning and Memory
  • 1 March 2006
Estradiol (17beta-E2) can have mnemonic-enhancing effects; however, its mechanisms for these effects are not well-understood. The present studies examined effects of 17beta-E2 and selective estrogenExpand
  • 115
  • 6
Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to prenatal restraint stress
It has been hypothesized that decreased neurogenesis in the dentate gyrus may be involved in mediating depressive disorders, which are 1.5–3 times more frequent in women than in men. Additionally,Expand
  • 136
  • 5
Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus
Estradiol (E(2)) can have classical actions via intracellular estrogen receptors (ERs) in the dorsal hippocampus, as well as effects independent of ERs ('non-genomic' mechanisms). These experimentsExpand
  • 73
  • 5
The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5α-reduced metabolites
Testosterone (T)'s positive hedonic effects may be mediated by actions of its metabolites, dihydrotestosterone (DHT) or 3alpha-androstanediol (3alpha-diol), in the nucleus accumbens (NA). InExpand
  • 96
  • 4
Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP.
Sex differences and estrous cycle variations in anxiolytic-like behaviors and progestin concentrations were examined. Proestrous (n=22), estrous (n=19), diestrous (n=20), and male (n=18) Long-EvansExpand
  • 97
  • 4
Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task
  • M. Rhodes, C. Frye
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1 July 2004
Gonadal hormones, such as estrogen, can alter cognitive performance. The present studies investigated the relationship between performance on the inhibitory avoidance task and endogenous fluctuationsExpand
  • 66
  • 4