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Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women.
TLDR
The hypothesis that the reduction in activation frequency caused by the antiresorptive effect of ALN is followed by a prolonged secondary Mineralization that increases the percentage of bone structure units having reached a maximum degree of secondary mineralization and contributes to improved bone strength is supported. Expand
Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric Parameters
An 18‐month randomized double‐blind study was conducted in postmenopausal women with osteoporosis to compare the effects of once‐daily teriparatide 20 μg with alendronate 10 mg on boneExpand
The Degree of Mineralization of Bone Tissue Measured by Computerized Quantitative Contact Microradiography
TLDR
Contact quantitative microradiography using a computerized microdensitometric method, is described and allows the measurement of the mean degree of mineralization of bone (MDMB), which does not change with age, and is necessary for interpreting the changes in MDMB observed in bone conditions untreated or treated. Expand
Incorporation and distribution of strontium in bone.
TLDR
Infiltration of strontium into bone, mainly by exchange onto the crystal surface, is dependent on the duration of treatment, dose, gender, and skeletal site, and, in bone, between the different skeletal sites. Expand
Long‐Term Strontium Ranelate Administration in Monkeys Preserves Characteristics of Bone Mineral Crystals and Degree of Mineralization of Bone
TLDR
In monkeys, long‐termstrontium ranelate administration results in a dose‐dependent bone strontium uptake that preserves the degree of mineralization of bone and the bone mineral at the crystal level, showing its safety at bone mineral level. Expand
Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography.
TLDR
A calibration method was proposed to evaluate the three-dimensional distribution of the degree of mineralization within the sample and a theoretical linear relationship modeling the linear attenuation coefficient as a function of the hydroxyapatite concentrations was derived. Expand
The degree of mineralization is a determinant of bone strength: a study on human calcanei.
TLDR
The more the cancellous tissue was mineralized, the higher was its stiffness and compressive strength, which may explain the increase in bone strength when DMB is modified in a physiological range without necessary changes of BMV and bone microarchitecture. Expand
The mineralization of bone tissue: a forgotten dimension in osteoporosis research
TLDR
It is shown that Sr was heterogeneously distributed between new and old bone but in a dose-dependent manner without alteration of the crystal characteristics and the degree of mineralization of bone tissue, even after long-term administration of often high doses of SR. Expand
Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration
The analysis of the interaction of strontium (Sr) with bone mineral is of interest because a new agent containing Sr (S 12911) has shown positive effects on bone mass in various animal models ofExpand
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