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LY 117018
Known as:
Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-
, Lilly 117018
, LY-117018
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (4)
Estrogen Antagonists
Pyrrolidines
Selective Estrogen Receptor Modulators
Thiophenes
LY 139478
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
J. M. Schafer
,
E. Lee
,
+4 authors
V. Jordan
Clinical Cancer Research
2001
Corpus ID: 5821590
PURPOSE Cross-resistance is the primary issue facing the evaluation of new antiestrogens to treat metastatic breast cancer…
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Highly Cited
2001
Highly Cited
2001
Induction of Endothelial Nitric-oxide Synthase Phosphorylation by the Raloxifene Analog LY117018 Is Differentially Mediated by Akt and Extracellular Signal-regulated Protein Kinase in Vascular…
Koji Hisamoto
,
M. Ohmichi
,
+9 authors
Y. Murata
Journal of Biological Chemistry
2001
Corpus ID: 20394986
Raloxifene is a tissue-selective estrogen receptor modulator. The effect of estrogen on cardiovascular disease is mainly…
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1999
1999
Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.
A. Lucci
,
A. Giuliano
,
+4 authors
M. Cabot
International Journal of Oncology
1999
Corpus ID: 26039967
Previously we demonstrated that multidrug-resistant (MDR) cancer cells have elevated levels of a glycosylated form of ceramide…
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Review
1996
Review
1996
A pharmacological review of raloxifene
H. Bryant
,
A. Glasebrook
,
N. Yang
,
Masahiko Sato
Journal of Bone and Mineral Metabolism
1996
Corpus ID: 39115583
SummaryIn view of its highly tissue-selective pharmacological properties (i.e., relatively pure antagonist in reproductive tissue…
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Highly Cited
1991
Highly Cited
1991
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation
M. Koga
,
R. Sutherland
Journal of Steroid Biochemistry and Molecular…
1991
Corpus ID: 24634640
1989
1989
Antiestrogen inhibition of prolactin-induced growth of the Nb2 rat lymphoma cell line.
R. Biswas
,
B. Vonderhaar
Cancer Research
1989
Corpus ID: 9178027
The rat lymphoma cell line Nb2 is highly prolactin responsive in terms of growth. Estrogens are without effect in these cells…
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1987
1987
Additive growth-inhibitory effects of DL-alpha-difluoromethylornithine and antiestrogens on MCF-7 breast cancer cell line.
T. Thomas
,
D. Kiang
Biochemical and Biophysical Research…
1987
Corpus ID: 27810418
1986
1986
Antiestrogen action in the medial basal hypothalamus and pituitary of immature female rats: insights concerning relationships among estrogen, dopamine, and prolactin.
T. Toney
,
B. Katzenellenbogen
Endocrinology
1986
Corpus ID: 10719197
We have examined the effects of nonsteroidal antiestrogens (AEs) and estradiol (E) on dopamine (DA) levels and turnover rates in…
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Highly Cited
1985
Highly Cited
1985
Steroid modulation of Mullerian duct regression in the chick embryo.
John M. Hutson
,
P. K. Donahoe
,
D. Maclaughlin
General and Comparative Endocrinology
1985
Corpus ID: 46677956
1981
1981
Differential interaction of antiestrogens with cytosol estrogen receptors
L. Black
,
C. Jones
,
R. L. Goode
Molecular and Cellular Endocrinology
1981
Corpus ID: 2901323
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