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hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo
TLDR
It was found that lacZ expression was primarily limited to the central nervous system, but therein was widespread in neurons and ependyma, suggesting that the hGFAP promoter is active in a multi‐potential neural stem cell. Expand
Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells
TLDR
The hypothesis that different connexin channels show different permeabilities to second messenger molecules as well as metabolites and may fulfill in this way their specific role in growth control and differentiation of cell types is supported. Expand
Expression and functions of neuronal gap junctions
TLDR
The roles of connexin and pannexin genes in the formation of neuronal gap junctions are discussed, and recent functional analyses of electrical synapses that became possible through the characterization of mouse mutants that show targeted defects in con Nexin genes are evaluated. Expand
The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus
TLDR
It is demonstrated that astrocytic gap junctions accelerate potassium clearance, limit potassium accumulation during synchronized neuronal firing, and aid in radial potassium relocation in the stratum lacunosum moleculare, and it is suggested that the perpendicular array of individualAstrocytes in thestratum radiatum makes these cells ideally suited for spatial buffering of potassium released by pyramidal cells, independent of gap junctional coupling. Expand
Gap junctions and the connexin protein family.
TLDR
Functional properties, like permeabilities, charge selectivity and unitary conductivity were investigated after directed expression of these connexins in cultured cell lines or paired Xenopus oocytes and targeted deletion of their coding sequence in the mouse genome allowed study of the biological relevance of Cx37, CX40, Cx43 and Cx45 with regard to cardiovascular morphology and function. Expand
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome
TLDR
This review compares currently identified connexin genes in both the mouse and human genome and discusses the functions of gap junctions deduced from targeted mouse mutants and human genetic disorders. Expand
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
TLDR
Subjecting rat and mouse cortical astrocytes to “chemical ischemia” by inhibition of glycolytic and oxidative metabolism induced permeabilization of cells to Lucifer yellow and ethidium bromide before loss of membrane integrity determined by dextran uptake and lactate dehydrogenase release, suggesting that dye uptake is mediated by Cx43 hemichannels. Expand
Differential expression of three gap junction proteins in developing and mature brain tissues.
TLDR
The findings demonstrate that gap junction expression in the brain is diverse, with specific cell types expressing different connexins; this cell-specific distribution may imply differences in the function of these intercellular channels in different loci and developmental stages. Expand
Connexin 47 (Cx47)-Deficient Mice with Enhanced Green Fluorescent Protein Reporter Gene Reveal Predominant Oligodendrocytic Expression of Cx47 and Display Vacuolized Myelin in the CNS
TLDR
Colocalization of EGFP fluorescence and immunofluorescence of cell marker proteins revealed that Cx47 was mainly expressed in oligodendrocytes in highly myelinated CNS tissues and in few calcium-binding protein S100β subunit-positive cells but not in neurons or peripheral sciatic nerve. Expand
Targeted Ablation of Connexin26 in the Inner Ear Epithelial Gap Junction Network Causes Hearing Impairment and Cell Death
TLDR
It is concluded that prevention of cell death in the sensory epithelium is essential for any attempt to restore the auditory function in DFNB1 patients, and the Cx26-containing epithelial gap junction network isessential for cochlear function and cell survival. Expand
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