Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
- J. Rossant, R. Zirngibl, D. Cado, M. Shago, V. Giguère
- BiologyGenes & Development
- 1 August 1991
It is shown that a RA response element (RARE) present in the RAR beta gene can direct specific spatial and temporal expression of an hsplacZ transgene during mouse embryogenesis, suggesting that, in vivo, some of the morphogenetic effects of RA could be mediated through localized transcriptional activity controlled by the various RARs.
Orphan nuclear receptors: from gene to function.
- V. Giguère
- Biology, ChemistryEndocrine reviews
- 1 October 1999
I. Nuclear Receptors: General Concepts and Orphans in Search of a Home.
Transcriptional control of energy homeostasis by the estrogen-related receptors.
- V. Giguère
- BiologyEndocrine reviews
- 15 January 2008
Recent and rapid advances in understanding the functions of the ERRs in regulating bioenergetic pathways are reviewed, with an emphasis on their roles in the specification of energetic properties required for cell- and tissue-specific functions.
Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors
- F. Guillaumond, H. Dardente, V. Giguère, N. Cermakian
- Biology, PsychologyJournal of Biological Rhythms
- 1 October 2005
All members of the REV-ERB and ROR families are crucial components of the molecular circadian clock, and their strikingly different patterns of expression in nervous and peripheral tissues provide important insights into functional differences between circadian clocks within the organism.
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.
- G. Tremblay, A. Tremblay, V. Giguère
- Biology, ChemistryMolecular Endocrinology
- 1 March 1997
The results demonstrate that while ER beta shares many of the functional characteristics of ER alpha, the molecular mechanisms regulating the transcriptional activity of mER beta may be distinct from those of ERalpha.
Identification of a new class of steroid hormone receptors
- V. Giguère, N. Yang, Prudimar Segui, R. Evans
- Biology, MedicineNature
- 7 January 1988
Using the DNA-binding domain of the human oestrogen receptor cDNA as a hybridization probe, two cDNA clones encoding polypeptides with structural features suggestive of cryptic steroid hormone receptors which could participate in a new hormone response system are isolated.
Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.
- V. Giguère, M. Tini, G. Flock, E. Ong, R. Evans, G. Otulakowski
- Biology, ChemistryGenes & Development
- 1 March 1994
Results demonstrate that the amino-terminal domain and the zinc finger region work in concert to confer high affinity and specific DNA- binding properties to the ROR isoforms and suggest a novel strategy to control DNA-binding activity of nuclear receptors.
To ERR in the estrogen pathway
- V. Giguère
- BiologyTrends in endocrinology and metabolism
- 1 July 2002
Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β
- Jiangming Luo, R. Sladek, J. Bader, Annie Matthyssen, J. Rossant, V. Giguère
- Biology, MedicineNature
- 21 August 1997
The results indicate that ERR-β has an important role in early placentation, and suggest that an inductive signal originating from or modified by the chorion is required for normal trophoblast proliferation and differentiation.
Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling.
- V. Giguère
- BiologyEndocrine reviews
- 1 February 1994
The present understanding of how retinoids control cell functions stems directly from studies of steroid and thyroid hormones' action, and pioneering studies demonstrated that small hydrophobic ligands are able to cross passive cell types.
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