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Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion thatExpand
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Orphan nuclear receptors: from gene to function.
  • V. Giguère
  • Biology, Medicine
  • Endocrine reviews
  • 1 October 1999
I. Introduction II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of action III. Orphan Nuclear Receptors A. Definition B. Nomenclature C. Structural andExpand
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Transcriptional control of energy homeostasis by the estrogen-related receptors.
  • V. Giguère
  • Biology, Medicine
  • Endocrine reviews
  • 15 January 2008
Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated action of numerous transcription factors and associated coregulators. Several members of the nuclearExpand
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Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors
Circadian rhythms result from feedback loops involving clock genes and their protein products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important roles in the transcription ofExpand
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Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.
Estrogen receptor beta (ER beta) is a novel steroid receptor that is expressed in rat prostate and ovary. We have cloned the mouse homolog of ER beta and mapped the gene, designated Estrb, to theExpand
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Identification of a new class of steroid hormone receptors
The gonads and adrenal glands produce steroids classified into five major groups which include the oestrogens, progestins, androgens, glucocorticoids and mineralocorticoids. Gonadal steroids controlExpand
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Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.
Three isoforms of a novel member of the steroid hormone nuclear receptor superfamily related to the retinoic acid receptors have been identified. The three isoforms, referred to as ROR alpha 1, RORExpand
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Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β
Classical endocrine studies have shown that steroid hormones are required for the maintenance of pregnancy and placental viability. The oestrogen-receptor-related receptor β (ERR-β) is an orphanExpand
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Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1.
The estrogen receptors (ERs) alpha and beta possess a constitutive N-terminal activation function (AF-1) whose activity can be modulated by kinase signalling pathways. We demonstrate here thatExpand
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Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling.
  • V. Giguère
  • Biology, Medicine
  • Endocrine reviews
  • 1 February 1994
VITAMIN A and its biologically active derivatives, retinal and retinoic acid (RA), are essential for the health and survival of the individual. These natural compounds, together with a largeExpand
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