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X-Box Binding Protein 1, Human

Known as: Tax-Responsive Element-Binding Protein 5, TREB5 protein, human, tax-responsive element-binding protein 5, human 
X-box binding protein 1 (261 aa, ~29 kDa) is encoded by the human XBP1 gene. This protein is a bZIP transcription factor that is involved in both the… 
National Institutes of Health

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Related topics

8 relations
DNA-Binding ProteinsGenes, RegulatorTranscription factor genesTranscriptional Regulation

Broader (1)

X-Box Binding Protein 1

Papers overview

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Highly Cited
2015
Highly Cited
2015
Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production
IL-1β and TNF-α are important proinflammatory cytokines that respond to mutated self-antigens of tissue damage and exogenous… 
Highly Cited
2014
Highly Cited
2014
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We… 
Highly Cited
2012
Highly Cited
2012
Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1
Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However… 
Highly Cited
2012
Highly Cited
2012
High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency
During B cell terminal differentiation, a complex set of transcription factors interact to drive the phenotypic and functional… 
Highly Cited
2012
Highly Cited
2012
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor… 
Highly Cited
2010
Highly Cited
2010
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress… 
Highly Cited
2009
Highly Cited
2009
Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca2+ Store Expansion Is Mediated by X-box Binding Protein-1*
Inflamed cystic fibrosis (CF) human bronchial epithelia (HBE), or normal HBE exposed to supernatant from mucopurulent material… 
Highly Cited
2009
Highly Cited
2009
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
XBP‐1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to… 
Highly Cited
2008
Highly Cited
2008
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER… 
Highly Cited
2007
Highly Cited
2007
Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas.
BACKGROUND Human X-box binding protein 1 (XBP-1) is a transcription factor essential for hepatocyte growth, as well as for plasma… 
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