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Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila.
To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty-seven percent of theExpand
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Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking.
The apical surface of mammalian urothelium is covered by 16-nm protein particles packed hexagonally to form 2D crystals of asymmetric unit membranes (AUM) that contribute to the remarkableExpand
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Light-Mediated TIM Degradation within Drosophila Pacemaker Neurons (s-LNvs) Is Neither Necessary nor Sufficient for Delay Zone Phase Shifts
Circadian systems are entrained and phase shifted by light. In Drosophila, the model of light-mediated phase shifting begins with photon capture by CRYPTOCHROME (CRY) followed by rapid TIMELESS (TIM)Expand
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Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associatedExpand
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Nascent-Seq analysis of Drosophila cycling gene expression
Significance Statement Rhythmic mRNA expression is a hallmark of circadian rhythms. To address this regulation in Drosophila, we used high throughput sequencing to compare nascent RNA and mRNA levelsExpand
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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNAExpand
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IRE1&agr; RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers
  • H. Xie, C. Tang, +10 authors M. Simon
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 2 April 2018
Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent downstream effectorsExpand
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Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization
To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1 deficiency, IRE1 switches to performExpand
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Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation*
Torsin ATPases are the only representatives of the AAA+ ATPase family that reside in the lumen of the endoplasmic reticulum (ER) and nuclear envelope. Two of these, TorsinA and TorsinB, are anchoredExpand
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Secretory IgM Exacerbates Tumor Progression by Inducing Accumulations of MDSCs in Mice
In a mouse model of chronic lymphocytic leukemia, production of secretory IgM led to more MDSCs, fewer T cells, and shorter survival times for the mice. Thus, secretory IgM may aggravate theExpand
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