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Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genomeExpand
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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viralExpand
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CD1 expression on antigen-presenting cells.
CD1 proteins present self and microbial glycolipids to CD 1-restricted T cells, or in the case of CD1d, to NKT cells. The CD1 family in humans consists of group I proteins CDla, CDlb, CDlc, and CDleExpand
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XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
XBP‐1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity toExpand
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In vivo discovery of immunotherapy targets in the tumour microenvironment
Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced disease. However, the regulatory switchesExpand
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The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy
Anti-inflammatories prevent surgery-induced outgrowth of distant tumors in mouse models and may reduce early metastatic relapse in patients. Can wound healing worsen metastasis? Relatively earlyExpand
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Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells
Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum (ER) chaperone that loads lipids onto apolipoprotein B, also regulates CD1d presentation of glycolipid antigens in the liverExpand
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IAP inhibitors enhance co-stimulation to promote tumor immunity
The inhibitor of apoptosis proteins (IAPs) have recently been shown to modulate nuclear factor κB (NF-κB) signaling downstream of tumor necrosis factor (TNF) family receptors, positioning them asExpand
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Anti–CTLA-4 therapy requires an Fc domain for efficacy
Significance Ipilimumab, an antibody that recognizes cytotoxic T lymphocyte antigen (CTLA)-4, was the first approved “checkpoint”-blocking anticancer therapy. In mice, the response to antibodiesExpand
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Sortase-catalyzed transformations that improve the properties of cytokines
Recombinant protein therapeutics often suffer from short circulating half-life and poor stability, necessitating multiple injections and resulting in limited shelf-life. Conjugation to polyethyleneExpand
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