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The genetics of ageing
  • C. Kenyon
  • Biology, Medicine
  • Nature
  • 24 March 2010
The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that overExpand
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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growthExpand
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Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor
The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and weExpand
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A C. elegans mutant that lives twice as long as wild type
WE have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type. This lifespan extension, theExpand
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The Plasticity of Aging: Insights from Long-Lived Mutants
  • C. Kenyon
  • Biology, Medicine
  • Cell
  • 25 February 2005
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. These mutations have revealed evolutionarilyExpand
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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homologExpand
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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3-kinase (PIExpand
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The nematode Caenorhabditis elegans.
  • C. Kenyon
  • Biology, Medicine
  • Science
  • 10 June 1988
In Caenorhabditis elegans patterns of cell division, differentiation, and morphogenesis can be observed with single-cell resolution in intact, living animals. Mechanisms that determine behaviors ofExpand
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Rates of Behavior and Aging Specified by Mitochondrial Function During Development
To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA interferenceExpand
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Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.
The genetic analysis of life span has revealed many interesting genes and pathways; however, our understanding of aging has been limited by the lack of a way to assay the aging process itself. HereExpand
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