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XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
XBP‐1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity toExpand
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Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking.
The apical surface of mammalian urothelium is covered by 16-nm protein particles packed hexagonally to form 2D crystals of asymmetric unit membranes (AUM) that contribute to the remarkableExpand
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Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly
Urothelial plaques consist of four major uroplakins (Ia, Ib, II, and III) that form two-dimensional crystals covering the apical surface of urothelium, and provide unique opportunities for studyingExpand
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Synergism of Rana catesbeiana ribonuclease and IFN‐γ triggers distinct death machineries in different human cancer cells
Rana catesbeiana ribonuclease (RC‐RNase) possesses tumor‐specific cytotoxicity, which can be synergized by IFN‐γ. However, it is unclear how RC‐RNase and RC‐RNase/IFN‐γ induce cell death. In thisExpand
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Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associatedExpand
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Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy
Objectives:To determine the incidence, clinical manifestations and risk factors for immune reconstitution inflammatory syndrome (IRIS) in young children initiating highly active antiretroviralExpand
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Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial.
CONTEXT Protease inhibitor (PI)-based therapy is recommended for infants infected with human immunodeficiency virus (HIV) who were exposed to nevirapine for prevention of mother-to-child HIVExpand
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Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.
Chronic lymphocytic leukemia (CLL) represents 30% of adult leukemia. TCL1 is expressed in ~ 90% of human CLL. Transgenic expression of TCL1 in murine B cells (Eμ-TCL1) results in mouse CLL. Here weExpand
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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNAExpand
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Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers.
BACKGROUND Early weaning has been recommended to reduce postnatal human immunodeficiency virus (HIV) transmission. We evaluated the safety of stopping breast-feeding at different ages for mortalityExpand
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