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VP-16

Known as: VP16, drug vp 16, VP 16 
National Institutes of Health

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Broader (1)

Etoposide

Papers overview

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Highly Cited
2003
Highly Cited
2003
Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
The herpes simplex virus 1 (HSV-1) replicative cycle begins by binding of the viral activator, VP16, to a set of sequences in the… 
Highly Cited
1998
Highly Cited
1998
Acute overexpression of wt p53 facilitates anticancer drug‐induced death of cancer and normal cells
The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53… 
Highly Cited
1998
Highly Cited
1998
Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis.
Apoptosis is cellular suicide functionally opposite of mitosis. It plays an important role in tissue growth control and removal… 
Highly Cited
1992
Highly Cited
1992
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia…
We have recently demonstrated that bufalin is a new potent inducer of the differentiation of human myeloid leukemia cells. The… 
Highly Cited
1992
Highly Cited
1992
Structural studies of the acidic transactivation domain of the Vmw65 protein of herpes simplex virus using 1H NMR.
We have overproduced and purified the carboxy-terminal transactivation domain of Vmw65 (VP16) of herpes simplex virus, and… 
Highly Cited
1990
Highly Cited
1990
Chromosome aberrations induced by etoposide (VP‐16) are not random
The clastogenic effect of etoposide, an anti‐cancer chemotherapeutic drug, was investigated in vitro on lymphocytes of 5 healthy… 
Highly Cited
1987
Highly Cited
1987
Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987…
In a phase I/II study, 47 patients (median age, 24 years) with hematologic malignancies (33 patients with acute leukemia not in… 
Highly Cited
1986
Highly Cited
1986
Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function.
Etoposide (VP16) pharmacokinetics was investigated in three groups of cancer patients: a control group of 18 patients with renal… 
Highly Cited
1984
Highly Cited
1984
Pharmacokinetics of etoposide (VP16) in children and adolescents with refractory solid tumors.
The clinical pharmacokinetics of etoposide were studied in eight pediatric patients with refractory solid tumors. The alpha-phase… 
Highly Cited
1983
Highly Cited
1983
Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.
The effects of the anticancer drugs 4′-demethylepipodophyllotoxin thenylidene β-d-glucoside and 4′-demethylepipodophyllotoxin… 
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