R. Tjian

Publications345
h-index125
Citations56,996
Highly Influential Citations2,071
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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.
The Drosophila insulin receptor (dInR) regulates cell growth and proliferation through the dPI3K/dAkt pathway, which is conserved in metazoan organisms. Here we report the identification and… Expand
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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome… Expand
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Transcription regulation and animal diversity
Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic… Expand
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Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.
The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review… Expand
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Orchestrated response: a symphony of transcription factors for gene control.
An enormous body of work generated over the past three decades has revealed that eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly regulated at many levels.… Expand
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Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
The general transcription factor TFIID is a multiprotein complex containing the TATA-binding protein and several associated factors (TAFs), some of which may function as coactivators that are… Expand
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p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.
The tumor suppressor protein p53 is a transcriptional regulator that enhances the expression of proteins that control cellular proliferation. The multisubunit transcription factor IID (TFIID) is… Expand
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A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.
Activation of transcription by the promoter-specific factor Sp1 requires coactivators that are tightly associated with the TATA-box-binding protein (TBP) in the TFIID complex. Recent work has shown… Expand
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Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
We have analyzed the expression pattern of transcription factor AP-2 in mouse embryos to evaluate the potential of AP-2 as a regulator during vertebrate development. A partial cDNA encoding AP-2 was… Expand
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Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.
Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and… Expand
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