R. Tjian

Publications441
h-index137
Citations68,624
Highly Influential Citations2,540
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Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.
TLDR
This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors in mammalian DNA binding transcription factors. Expand
The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway
TLDR
It is demonstrated that yan can repress transcription and that this repression activity is negatively regulated by the Ras1/MAPK signal, most likely through direct phosphorylation of yan by MAPK. Expand
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
TLDR
It is shown that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. Expand
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.
TLDR
The identification and functional characterization of the Drosophila forkhead-related transcription factor d FOXO is reported, establishing dFOXO as a key transcriptional regulator of the insulin pathway that modulates growth and proliferation. Expand
Transcription regulation and animal diversity
TLDR
Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrates have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. Expand
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
TLDR
The isolation and characterization of the first gene encoding a TAF protein TAF110 revealed the presence of several glutamine- and serine/threonine-rich regions reminiscent of the protein-protein interaction domains of the regulatory transcription factor Sp1 that are involved in transcription activation and multimerization. Expand
Affinity purification of sequence-specific DNA binding proteins.
TLDR
This method provides a means for the purification of rare sequence-specific DNA binding proteins, such as Sp1 and CAAT-binding transcription factor, by using tandem affinity columns containing different protein binding sites. Expand
Orchestrated response: a symphony of transcription factors for gene control.
TLDR
The question of how gene expression is regulated in complex eukaryotic genomes has re-focused on the molecular machines that have evolved to navigate through chromatin and mediate transcriptional control. Expand
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation
TLDR
Results suggest that one or more of the TAF polypeptides confer coactivator function in NTF-1, a developmentally regulated transcription factor in Drosophila. Expand
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
TLDR
Results suggest that direct binding of Sp 1 to sequences in the upstream promoter element is the mechanism by which this factor activates transcription by RNA polymerase II at the SV40 early promoter. Expand
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