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Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
TLDR
This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role. Expand
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
TLDR
The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract. Expand
Identification of two lysosomal membrane glycoproteins
TLDR
It is postulated that these glycoproteins, as major protein constituents of the lysosomal membrane, have important roles in lysOSomal structure and function. Expand
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
TLDR
Genetically redirected T cells have promise of targeting T lymphocytes to tumor antigens, confer resistance to the tumor microenvironment, and providing immunosurveillance in the context of poorly immunogenic tumors. Expand
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
TLDR
Results imply that the MDR1 gene could be activated during tumor progression associated with mutations in Ras and p53, and imply that drug resistance in human cancer is associated with overexpression of the multidrug resistance (MDR1) gene. Expand
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
TLDR
It is proposed that dansylcadaverine inhibits EGF internalization by preventing it from clustering in clathrin-coated pits. Expand
Expression of a multidrug-resistance gene in human tumors and tissues.
TLDR
The results suggest that measurement of mdr1 RNA may prove to be a valuable tool in the design of chemotherapy protocols and controlled clinical studies will be required. Expand
Genetic analysis of the multidrug transporter.
TLDR
This review focuses on the genetic and molecular genetic analysis of the human multidrug transporter, including structure-function analysis, pre- and posttranslational regulation of expression, the role of gene amplification in increased expression, and the properties of transgenic and "knock-out" mice. Expand
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
TLDR
It is indicated that cells in patients that express the MDR1 transporter will be relatively resistant to the anti-viral effects of the HIV-1 protease inhibitors, and that absorption, excretion, and distribution of these inhibitors in the body may be affected by the multidrug transporter. Expand
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