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Biochemistry of multidrug resistance mediated by the multidrug transporter.
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
- S. Ambudkar, S. Dey, C. Hrycyna, M. Ramachandra, I. Pastan, M. Gottesman
- BiologyAnnual review of pharmacology and toxicology
This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
- F. Thiebaut, T. Tsuruo, H. Hamada, M. Gottesman, I. Pastan, M. Willingham
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 November 1987
The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
Identification of two lysosomal membrane glycoproteins
- J. Chen, T. Murphy, M. Willingham, I. Pastan, J. August
- Biology, ChemistryThe Journal of cell biology
- 1 July 1985
It is postulated that these glycoproteins, as major protein constituents of the lysosomal membrane, have important roles in lysOSomal structure and function.
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
Results imply that the MDR1 gene could be activated during tumor progression associated with mutations in Ras and p53, and imply that drug resistance in human cancer is associated with overexpression of the multidrug resistance (MDR1) gene.
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- C. Carpenito, M. Milone, C. June
- Biology, MedicineProceedings of the National Academy of Sciences
- 3 March 2009
Genetically redirected T cells have promise of targeting T lymphocytes to tumor antigens, confer resistance to the tumor microenvironment, and providing immunosurveillance in the context of poorly immunogenic tumors.
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
- C. Gorman, G. Merlino, M. Willingham, I. Pastan, B. Howard
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1982
The results indicate that the Rous sarcoma virus LTR can direct synthesis of high levels of functional mRNA and has a wide expression range.
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
It is indicated that cells in patients that express the MDR1 transporter will be relatively resistant to the anti-viral effects of the HIV-1 protease inhibitors, and that absorption, excretion, and distribution of these inhibitors in the body may be affected by the multidrug transporter.
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
- H. Haigler, F. Maxfield, M. Willingham, I. Pastan
- BiologyThe Journal of biological chemistry
- 25 February 1980
It is proposed that dansylcadaverine inhibits EGF internalization by preventing it from clustering in clathrin-coated pits.