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Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
The temporal pattern of expression of these three C/EBP isoforms during adipocyte differentiation may reflect the underpinnings of a regulatory cascade that controls the process of terminal cell differentiation. Expand
Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
It is discovered that exposure of cell or tissue lysates to a biotinylated isoxazole (b-isox) chemical precipitated hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules, offering a framework for understanding the function of LC sequences as well as an organizing principle for cellular structures that are not membrane bound. Expand
Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes
Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time. Expand
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
In cultured mammalian cells, inappropriate accumulation of HIF caused by forced expression of the HIF-1α subunit under normoxic conditions was attenuated by coexpression of HPH, indicating that HPH is an essential component of the pathway through which cells sense oxygen. Expand
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
EPAS1 expression is limited to the endothelium of mouse embryos and is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2, raising the possibility that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia. Expand
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.
It is predicted that VP16 achieves IE gene specificity via protein: protein, rather than protein: DNA, interaction, according to the results presented in this and the accompanying paper. Expand
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares notable sequence similarity with a segment of the cellular Myc transforming protein, and may represent a characteristic property of a new category of DNA binding proteins. Expand
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.
It is discovered that ectopic expression of C/EBP beta in multipotential NIH-3T3 cells results in their conversion into committed adipoblasts capable, upon hormonal stimulation, of synchronous and uniform differentiation into fat-laden adipocytes. Expand
Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors
The reduced forms of the redox cofactors, NAD(H) and NADP(H), strongly enhance DNA binding of the Clock:BMal1 and NPAS2:BMAL1 heterodimers, whereas the oxidized forms inhibit, raising the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state. Expand
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
It is shown that the peptides encoded by the expanded repeats in the C9orf72 gene interfere with the way cells make RNA and kill cells, providing evidence that dipeptide repeat proteins can cause toxicity directly. Expand