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Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB
TLDR
It is established that different activators interact with distinct TAFs in the TFIID complex and that TAF’s can contact both activators and basal factors.
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
TLDR
It is shown that DICER1 deficit or Alu RNA exposure activates the NLRP3 inflammasome and triggers TLR-independent MyD88 signaling via IL18 in the RPE and reveals a function of the inflammaome outside the immune system and an immunomodulatory action of mobile elements.
Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock.
TLDR
It is shown that human Alu RNA, transcribed from short interspersed elements (SINEs), is a transacting transcriptional repressor during the cellular heat shock response.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
TLDR
It is reported that triptolide covalently binds to human XPB, a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription and likely nucleotide excision repair.
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
TLDR
Findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness.
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
TLDR
A fundamental role for actin in the initiation of transcription by RNA polymerase II is suggested after it was demonstrated that antibodies directed against β-actin, but not muscle actin, inhibited transcription in vivo and in vitro.
Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II
TLDR
The results suggest a role for TFIIH-associated helicase activity or supercoiling during promoter clearance rather than open complex formation, and establish abortive initiation as a useful assay for studying functional initiation complex formation in defined eukaryotic transcription systems.
The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock
TLDR
During the heat shock response in mouse cells, a small noncodingRNA polymerase III transcript, B2 RNA, associates with RNA polymerase II and represses transcription of specific mRNA genes, defining a unique transcriptional regulatory mechanism involving an RNA regulator and revealing how mRNA transcription is repressed upon heat shock.
Phosphatase Inhibition Leads to Histone Deacetylases 1 and 2 Phosphorylation and Disruption of Corepressor Interactions*
TLDR
A novel link between HDAC phosphorylation and the control of protein-protein interactions is established and a mechanism for relief of deacetylase-catalyzed transcriptional repression by phosphorylated-dependent signaling is suggested.
Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex.
TLDR
The results suggest that TFIIA may form a specific complex with both TAFs and other components of the transcriptional machinery during formation of the initiation complex.
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