R. Roeder

Publications696
h-index154
Citations87,297
Highly Influential Citations4,064
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
TLDR
A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
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The role of general initiation factors in transcription by RNA polymerase II.
  • R. Roeder
  • Biology
    Trends in biochemical sciences
  • 1 September 1996
View on PubMed
Regulation of MLL1 H3K4 methyltransferase activity by its core components
TLDR
This study reports the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex and demonstrates that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate.
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WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development
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Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination
TLDR
It is demonstrated that human peptidylarginine deiminase 4 (PAD4) regulates histone Arg methylation by converting methyl-Arg to citrulline and releasing methylamine, and that PAD4 activity is linked with the transcriptional regulation of estrogen-responsive genes in MCF-7 cells.
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Crystal structure of a TFIIB–TBP–TATA-element ternary complex
The crystal structure of the transcription factorIIB (TFIIB)/TATA box-binding protein (TBP)/ TATA-element ternary complex is described at 2.7 Å resolution. Core TFIIB resembles cyclin A, and…
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The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
TLDR
The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of protein-coding genes in metazoan cells and can interact with and coordinate the action of numerous other co-activators and co-repressors, including those acting at the level of chromatin.
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Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF
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RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells
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