Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
- P. Kastner, A. Krust, P. Chambon
- BiologyEMBO Journal
- 1 May 1990
Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15.
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
- A. Helmrich, M. Ballarino, L. Tora
- BiologyMolecules and Cells
- 23 December 2011
seqMINER: an integrated ChIP-seq data interpretation platform
An integrated portable ChIP-seq data interpretation platform called seqMINER, with optimized performances for efficient handling of multiple genome-wide datasets, which can handle the biological complexity of most experimental situations and proposes methods to the user for data classification according to the analysed features.
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
It is highlighted that deregulation of the global and/or specific AT activities of these complexes leads to the cancerous transformation of the cells highlights their importance in cellular processes.
The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements
Interestingly, the reduction of the SAGA deubiquitination activity and the parallel increase in H2B ubiquitation at inducible target genes before activation do not induce aberrant gene expression, indicating that different dynamic equilibriums of H 2B ubiquitination/deubiquITination are established at different gene regulatory elements and that H2 B ubiquitinations changes are necessary but not sufficient to trigger parallel activation of gene expression.
The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.
- L. Tora, A. Mullick, D. Metzger, M. Ponglikitmongkol, I. Park, P. Chambon
- Biology, MedicineEMBO Journal
- 1 July 1989
We demonstrate here that the human oestrogen receptor (hER) cDNA clone pOR8 obtained from MCF‐7 cells contains an artefactual point mutation which results in the substitution of a valine for a…
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
- Y. Trottier, Y. Lutz, J. Mandel
- BiologyNature
- 23 November 1995
The characterization of a monoclonal antibody is reported that selectively recognizes polyglutamine expansion in the proteins implicated in HD and in spinocerebellar ataxia (SCA) 1 and 3 and detects specific pathological proteins expected to contain such expansion.
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
- K. Gradin, J. McGuire, L. Poellinger
- Biology, ChemistryMolecular and Cellular Biology
- 1 October 1996
It is demonstrated that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo, and observed that Hif-1alpha was associated with the molecular chaperone hsp90, possibly by binding an as yet unknown class of ligands.
hTAF(II)68, a novel RNA/ssDNA‐binding protein with homology to the pro‐oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.
- A. Bertolotti, Y. Lutz, D. J. Heard, P. Chambon, L. Tora
- BiologyEMBO Journal
- 1 September 1996
The cloning and characterization of a novel human TBP‐associated factor, hTAF(II)68, which contains a consensus RNA‐binding domain (RNP‐CS) and binds not only RNA, but also single stranded DNA, is reported.
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