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Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15.
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
The deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo.
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
The results show that, on the longest human genes, collisions of the transcription machinery with a replication fork are inevitable, creating R-loops and consequent CFS formation, and functional replication machinery needs to be involved in the resolution of conflicts between transcription and replication machineries to ensure genomic stability.
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
It is highlighted that deregulation of the global and/or specific AT activities of these complexes leads to the cancerous transformation of the cells highlights their importance in cellular processes.
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3
- Angèle Santenard, Céline Ziegler-Birling, M. Koch, L. Tora, Andrew J. Bannister, Maria-Elena Torres-Padilla
- Biology, MedicineNature Cell Biology
- 1 September 2010
It is shown that the histone variant H3.3, and in particular lysine 27, is required for the establishment of heterochromatin in the mouse embryo and a role for a modifiable residue within a histone-variant-specific context during reprogramming is demonstrated.
seqMINER: an integrated ChIP-seq data interpretation platform
An integrated portable ChIP-seq data interpretation platform called seqMINER, with optimized performances for efficient handling of multiple genome-wide datasets, which can handle the biological complexity of most experimental situations and proposes methods to the user for data classification according to the analysed features.
The N‐terminal part of TIF1, a putative mediator of the ligand‐dependent activation function (AF‐2) of nuclear receptors, is fused to B‐raf in the oncogenic protein T18.
It is proposed that TIF1, which contains several conserved domains found in transcriptional regulatory proteins, is a mediator of ligand‐dependent AF‐2, and the N‐terminal moiety is fused to B‐raf in the mouse oncoprotein T18.
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
The characterization of a monoclonal antibody is reported that selectively recognizes polyglutamine expansion in the proteins implicated in HD and in spinocerebellar ataxia (SCA) 1 and 3 and detects specific pathological proteins expected to contain such expansion.
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
- K. Gradin, J. McGuire, +6 authors L. Poellinger
- Biology, MedicineMolecular and cellular biology
- 1 October 1996
It is demonstrated that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo, and observed that Hif-1alpha was associated with the molecular chaperone hsp90, possibly by binding an as yet unknown class of ligands.
The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.
- L. Tora, A. Mullick, D. Metzger, M. Ponglikitmongkol, I. Park, P. Chambon
- Biology, MedicineThe EMBO journal
- 1 July 1989
We demonstrate here that the human oestrogen receptor (hER) cDNA clone pOR8 obtained from MCF‐7 cells contains an artefactual point mutation which results in the substitution of a valine for a…